http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2007141625-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0046 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y107-03003 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0048 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-06 |
| filingDate | 2006-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2007141625-A |
| titleOfInvention | OPTIONAL FORMS OF URATOXIDASE AND THEIR APPLICATION |
| abstract | 1. An isolated, shortened mammalian uricase containing the amino acid sequence of a mammalian uricase, shortened from the amino terminus or carboxy terminus, and from the amino and carboxy terminus by about 1-13 amino acids and further containing an amino acid substitution at position 46.! 2. The uricase of claim 1, further comprising an amino terminal amino acid, wherein the amino terminal amino acid is alanine, glycine, proline, serine or threonine. ! 3. The uricase of claim 2, wherein the amino terminal amino acid is threonine. ! 4. The uricase according to claim 1, where the replacement is a replacement with threonine or alanine. ! 5. Urikase according to claim 3, where the replacement is the replacement with threonine. ! 6. The uricase according to claim 5, containing the amino acid sequence of SEQ ID No. 8.! 7. Uricase according to any one of claims 1 to 6, wherein the uricase is conjugated to a polymer. ! 8. The conjugate polyethylene glycol-uricase containing uricase according to any one of claims 1 to 6. ! 9. The conjugate of claim 8, containing from 2 to 12 polyethylene glycol molecules per uricase subunit. ! 10. The conjugate according to claim 9, containing from 3 to 10 polyethylene glycol molecules per uricase subunit. ! 11. The conjugate of claim 8, where each polyethylene glycol molecule had a molecular weight of from 1 kD to 100 kD. ! 12. The conjugate according to claim 11, where each polyethylene glycol molecule had a molecular weight of from 1 kD to 50 kD. ! 13. The conjugate of claim 12, wherein each polyethylene glycol molecule has a molecular weight of 5 kD to 20 kD. ! 14. The conjugate of claim 13, wherein each polyethylene glycol molecule has a molecular weight of approximately 10 kD. ! 15. A pharmaceutical composition comprising uricase according to any one of claims 1 to 5. ! 16. A pharmaceutical composition comprising the conjugate of claim 8. ! 17. The composition according to clause 15, with |
| priorityDate | 2005-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 65.