http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2007136430-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D499-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0053 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-22 |
| filingDate | 2006-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2007136430-A |
| titleOfInvention | NEW POLYMORPHIC FORMS OF RIFAXIMINE, METHODS FOR THEIR PRODUCTION AND THEIR APPLICATION IN MEDICINES |
| abstract | 1. A rifaximin antibiotic polymorph called rifaximin δ, characterized by a water content in the range of 2.5 to 6% w / w, preferably 3.0 to 4.5%, and a powder X-ray diffraction pattern showing peaks at diffraction angles 2θ 5.7 ° ± 0.2, 6.7 ° ± 0.2, 7.1 ° ± 0.2, 8.0 ° ± 0.2, 8.7 ° ± 0.2, 10.4 ° ± 0.2, 10.8 ° ± 0.2, 11.3 ° ± 0.2, 12.1 ° ± 0.2, 17.0 ° ± 0.2, 17.3 ° ± 0.2, 17.5 ° ± 0.2, 18.5 ° ± 0.2, 18.8 ° ± 0.2, 19.1 ° ± 0.2, 21.0 ° ± 0.2, 21.5 ° ± 0.2. ! 2. The rifaximin antibiotic polymorph, called rifaximin ε, is characterized by a powder X-ray diffractogram showing peaks at diffraction angles of 2θ 7.0 ° ± 0.2, 7.3 ° ± 0.2, 8.2 ° ± 0.2, 8 , 7 ° ± 0.2, 10.3 ° ± 0.2, 11.1 ° ± 0.2, 11.7 ° ± 0.2, 12.4 ° ± 0.2, 14.5 ° ± 0 , 2, 16.3 ° ± 0.2, 17.2 ° ± 0.2, 18.0 ° ± 0.2, 19.4 ° ± 0.2. ! 3. A method for producing rifaximins δ and ε, characterized in that the molar equivalent of rifamycin O is reacted with an excess of 2-amino-4-methylpyridine, preferably from 2.0 to 3.5 molar equivalents, in a solvent mixture prepared from water and ethyl alcohol in a volume ratio of from 1: 1 to 2: 1, for a period of time from 2 to 8 hours at a temperature of from 40 to 60 ° C, this reaction mass is treated at room temperature with a solution of ascorbic acid in a mixture of water, ethyl alcohol and concentrated aqueous hydrochloric acid, pH reaction The mass is adjusted to 2.0 with a concentrated aqueous hydrochloric acid solution, the suspension is filtered, the resulting solid is washed with the same water / ethyl alcohol solvent as used in the reaction, the crude rifaximin thus obtained is purified by dissolving it in ethyl alcohol at a temperature of 45 up to 65 ° C, causing its precipitation by the addition of water, preferably in mass quantities from 15 to 70% relative |
| priorityDate | 2005-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.