http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2007135271-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-14 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C217-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C217-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P23-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C217-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-54 |
| filingDate | 2006-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2007135271-A |
| titleOfInvention | PHOSPHATE SALTS OF 6-DIMETHYLAMINOMETHYL-1- (3-METHOXYPHENYL) -1, 3-DIHYDROXYCYCLOHEXANE COMPOUNDS |
| abstract | 1. 6-dimethylaminomethyl-1- (3-methoxyphenyl) -1,3-dihydroxycyclohexane compounds (I)! ! where R1 is OH,! R2 is OH, and! R3 is H or! R3 is OH, and! R2 is H and! R4 is CH3,! in the form of their salts with phosphoric acids, preferably pyrophosphoric acids and / or phosphoric acids. ! 2. The phosphate salts of claim 1, wherein the phosphoric acid is orthophosphoric acid. ! 3. Phosphate salts according to claim 2, characterized in that the compounds (I) in the salts have the configuration of the formula Ia! . ! 4. Phosphate salts according to claim 3, characterized in that each of R1 and R2 is OH, R3 is hydrogen, and R4 is CH3. ! 5. Phosphate salts according to claim 4 in the form of a racemic mixture, namely: in the form of (1RS, 3RS, 6RS) -6-dimethylaminomethyl-1- (3-methoxyphenyl) cyclohexane-1,3-diol. ! 6. Phosphate salts according to claim 4, characterized in that the compound of formula (I) is (+) - (1R, 3R, 6R) -6-dimethylaminomethyl-1- (3-methoxyphenyl) cyclohexane-1,3-diol or (-) - (1S, 3S, 6S) -6-dimethylaminomethyl-1- (3-methoxyphenyl) cyclohexane-1,3-diol. ! 7. A method for producing a phosphate salt according to one of claims 1 to 6, characterized in that the compound of general formula (I), optionally in the form of its salt, is reacted with phosphoric acid in the reaction medium. ! 8. The method according to claim 7, characterized in that the hydrochloride of compound (I) or the free base of formula (I) is reacted with phosphoric acid, preferably in a molar ratio between compound (I) and phosphoric acid in the range from 2: 1 to 1 : 2, preferably from 1.5: 1 to 1: 1.5, particularly preferably from 1.1: 1 to 1: 1.1. ! 9. The method according to claim 7 or 8, in which the base of formula (I) is suspended at a temperature in the range from 10 to 40 ° C, preferably from 20 to 30 ° C, os |
| priorityDate | 2005-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.