http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2007130406-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-18 |
| filingDate | 2006-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2007130406-A |
| titleOfInvention | RAPAMICIN CLEANING |
| abstract | 1. Rapamycin having a purity of more than 98% and a color index of yellowness of less than 1.! 2. Rapamycin according to claim 1, characterized in that it has an isomeric ratio of B: C greater than 30: 1. ! 3. Rapamycin according to claim 1, characterized in that it has an isomeric ratio of B: C greater than 35: 1. ! 4. A composition comprising rapamycin according to claim 1 and a physiologically compatible carrier. ! 5. A composition comprising rapamycin having an isomeric ratio of B: C greater than 30: 1. ! 6. The composition according to claim 5, characterized in that the isomeric ratio is greater than 35: 1. ! 7. A method for purifying rapamycin, comprising:! (a) treating rapamycin with chlorotrimethylsilane in an inert solvent in the presence of a suitable base to obtain rapamycin 31,42-bis-O-trimethylsilyl ether; ! (b) filtering rapamycin 31,42-bis-O-trimethylsilyl ether; ! (c) extracting rapamycin 31,42-bis-O-trimethylsilyl ether in heptane; ! (d) washing the extracted rapamycin 31,42-bis-O-trimethylsilyl ether; and! (e) deprotecting the extracted rapamycin 31,42-bis-O-trimethylsilyl ester with acid to produce rapamycin. ! 8. The method according to claim 7, characterized in that stage (d) includes:! (i) filtering the solution obtained in step (c); ! (ii) mixing the filtrate with charcoal; ! (iii) washing the filtrate with water and sodium bicarbonate; ! (iv) concentrating the filtrate; and! (v) dissolving the filtrate in a suitable solvent. ! 9. The method of claim 8, wherein the suitable solvent is selected from the group consisting of acetone, tetrahydrofuran, acetonitrile and acetic acid. ! 10. The method of claim 8, wherein the suitable solvent is acetone. ! 11. The method according to any one of claims 7-10, d� |
| priorityDate | 2005-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.