| abstract |
1. Chimeric polypeptide containing a) a first domain of a first intracellular loop (i1 loop) of a G protein-coupled receptor (GPCR), or a fragment thereof, and b) a second domain connected to the first domain, where the second domain is natural or artificial a hydrophobic residue penetrating into the cells that binds to the membrane, where the first domain does not contain the natural extracellular part of GPCR.2. A chimeric polypeptide according to claim 1, wherein the chimeric polypeptide binds to its related GPCR. The chimeric polypeptide according to claim 1, wherein the hydrophobic residue is attached to the N-terminal, C-terminal, amino acid between the C-terminal and N-terminal amino acid, or both the N-terminal and C-terminal of the first domain. The chimeric polypeptide according to claim 1, where the hydrophobic residue is a lipid, and where the hydrophobic residue is optionally selected from the group consisting of a nonanoyl residue (C); capril (C); undecanoyl (C); lauryl (C); tridecanoyl (C); myristyl (C); pentadecanoyl (C); palmityl (C); phytanyl (Cc substituted methyl); heptadecanoyl (C); stearyl (C); nonadecanoyl (C); arachidyl (C); geniaicosanil (C); Behenyl (C); trisizanil (C); and lignoceryl (C), where the hydrophobic residue is attached to the chimeric polypeptide by amide bonds, sulfhydryl groups, amines, alcohols, phenolic groups or carbon-carbon bonds. 5. The chimeric polypeptide of claim 4, wherein the hydrophobic residue is a palmityl residue. A chimeric polypeptide according to claim 4, wherein the hydrophobic residue is lithocholic acid or a salt thereof. The chimeric polypeptide according to claim 1, where the hydrophobic residue is selected from the group consisting of cholesterol, phospholipid, steroid, sphingosine, ceramide, octylglycine, 2-cyclohexylalanine, benzolylphenylalanine, |