| abstract |
1. A compound of the formula or a pharmaceutically acceptable salt thereof, wherein R, R, R, R, R, R, R and R are independently —H, halogen, —OH, —NH, —CN, —NO or —AB; R is O, S or NH ; A represents -SO-, -SONH-, -NHSO-, -NHCO-, -NHCONH-, -O-, -CO-, -OC (O) -, -C (O) O-, -CONH-, -CON (C-C1-6alkyl) -, -NH-, - (CH) -, -S-, or -C (S) -; B is -C-C1-6alkyl, -C-C1-6 alkenyl, -C-C1-6 alkynyl, -C- Monocyclic cycloalkyl, -C-Cbicyclic cycloalkyl, -C-Cmonocyclic cycloalkenyl, -C-Cbicyclic cycloalkenyl, - (nitrogen-containing 3-7-membered monocyclic heterocycle), - (nitrogen-containing 7-10-membered bicyclic heterocycle), - (3 monocyclic member heterocycle), - (7-10 membered bicyclic heterocycle), -aryl, -NZZ, - (C-C1-6 alkylene) -NZZ, -C (O) OH, -C (O) O- (C-C1-6 alkyl), —C (O) O-aryl or —C (NH) NH, each of which, with the exception of —NZZ, C (O) OH or —C (NH) NH, is unsubstituted or substituted with one or more substituents selected from - C (O) NH, -O- (C-C1-6 alkyl), -halogen, -OH, -NO, -NH, -CN, -C-C1-6 alkyl, -aryl, -C (O) OH or -C (O) O- (C-C1-6 alkyl); Z and Z are independently -H or -C-C1-6 alkyl which is unsubstituted or substituted by one or more substituents selected from -halogen, -OH or -N (Z) (Z), where Z and Z are independently -H or -C-C1-6 alkyl, which is unsubstituted substituted or substituted by one or more substituents selected from -halogen, -OH or -NH; or N, Z and Z taken together form - (a nitrogen containing 3-7 membered monocyclic heterocycle) or - (a nitrogen containing 7-10 membered bicyclic heterocycle), or N, Z and Z taken together form - (a nitrogen containing 3-7 -membered monocyclic heterocycle) or - (nitrogen-containing 7-10 membered bicyclic heterocycle); R represents -H, -C-Ci-alkyl, - (CH) -CN, - (CH) -aryl, - (CH) - (3-7 -membered monocyclic heterocycle), - (CH) - (7-10 membered bicyclic heterocycle), - (CH) -COO- (C-C1-6 alkyl), - (CH) -COO-aryl, - (CH) -COOH, -CONH- (CH) -COOH, -CONH |