| abstract |
Usage: as medicine as antibiotics. SUMMARY OF THE INVENTION: product: macrolide antibiotics of class I. where R CH C H or 3 25 iso C H, R2, R3 r n group; OR4-OH —OCOR6 l where R —C —C alkyl unsubstituted or substituted by a halogen atom, or OCO R a. where R a is C — C alkyl or benzyl Reagent 1: a compound of I, wherein OH; H; OR4 is a protected hydroxyl group. Reagent II: an oxidizing agent such as pyridini dichromate or N. N-dimethyl sulfoxide. Reaction conditions: in the presence of an activating agent such as oxalyl chloride in an organic solvent at temperatures from 70 ° C to 22 ° C, followed by removal, if necessary, by alkaline hydrolysis of the protected OR4 group, and isolation of the compound f-I where OR4-OH is an OH group, or, by the action of an acylating agent, it is converted to compound I, where OR4-OCOR6 group or CCA R6 group The daily dose of the compound is 1 - 2000 mg / kg body weight Activity against doubtful nematospiroids in mice at a dose of 10 mg / kg (subcutaneous) is 50 - 82%. 2 tab. |