http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-1782009-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_932a75bd3f5f0d49b2d8158a641b9d25 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-91 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-34 |
| filingDate | 1991-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1995-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f199a5d5b00667e59b1265feefab2de http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6b3e320c516c3748edeed756b526ccd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c30eaec3377a01b0ffc638a02651e96c |
| publicationDate | 1995-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-1782009-C |
| titleOfInvention | 5,7-o-bis-(diethylaminoethyl)-usninic acid ditartrate showing antitumor activity |
| abstract | FIELD: organic chemistry. SUBSTANCE: product: 5,7-O-(bis-(diethylaminoethyl)-usninic acid ditartrate, empirical formula is C 38 H 54 N 2 O 19 , m. p. is 105-106 ° C LD 50 for mice is 300-350 mg/kg, inhibits the growth of carcinosarcoma Walker (26.1% ), alveolar hepatocarcinoma PC-1 (29.2% ), lymphosarcoma Pliss (70.8%), prolongs life span of mice bearing strain P-388 (120.4% ). Reagent 1: usninic acid. Reagent 2: diethylchloroethylamine. Process conditions: heating at 45-50 C in the presence of calcined K 2 CO 3 and KOH. Reagent 3: tartaric acid. Synthesized compound is used in medicine. EFFECT: improved method of synthesis, enhanced antitumor effectiveness. |
| priorityDate | 1991-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.