http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-1781226-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_484caa25e1950c77a1afe8e548ce80d8 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-00 |
| filingDate | 1990-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1992-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57143661efc5211d1abe3b97a4d66e9a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e272e49ddf178175490cb7af9634ed9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c51085eb8a650be0081b623644d2fb28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c9c7522723e3e925003daff6297a25ff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56bdc3c6121b5f8986dd2add6b4b9360 |
| publicationDate | 1992-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-1781226-C |
| titleOfInvention | The method of obtaining pyroglutamyl-containing substrates |
| abstract | Usage: in medical and biological chemistry. SUBSTANCE: method for preparing pyroglutamyl-containing enzyme substrates of the general formula: L-GLp-MR-C CH-C-N02 СН СН-СН where R-H, -Phe, -Phe-Ala, -Ala-Ala-Leu. Reagent 1: L-pyroglutamic acid chloride, obtained immediately before the reaction by treating L-pyroglutamic acid with phosphorus dichloride at a temperature of -5-10 ° C in an absolute chlorinated hydrocarbon:. Reagent 2: RNH-C-CH-CN (2 sn-sn-Sn. The process is carried out in the presence of a base, followed by exposure for 16 hours. It is preferable to obtain compounds I, where, an excess of n-nitroaniline is used as the base. Yield 70- 95% .1 cp f-crystals, 2 tablets with С |
| priorityDate | 1990-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 57.