| abstract |
Usage: as an inhibitor of the enzyme 5-lipoxygenase and / or leukotriene receptor blocker. SUMMARY OF THE INVENTION: a product of general formula The invention relates to a method for producing a racemic or optically active heterocyclic compound of general formula I hA Y1 G f3 x4CH2) mR A (7t Za X (Zf) th h O / Y Y2, fjxrx -to2) m-R2 Vx-iCz% where n is 0 or 1; t 1-X1 -CH20.S; X2-CH3, O; Y1 is H; Y2 is OH; Z is CHz; Z2-CH, Y1-2-pyridyl, 2-quinolyl, 2-benzothiazolyl, 2-pyrimidinyl or 5-fluoro-2-benzothiazolyl; Ra is phenyl, pyridyl or phenyl substituted with carboxy, methyl or methoxy. Reagent 1: a compound of the general formula HO X. for Y2 Z (CH2) m-R2) nE where n, t,,, b and P3 have the indicated meanings. Reagent 2: Ri-CH2-X3, where RI has the indicated meanings, X3 is a nucleophilically substituted group. Reaction conditions: in the presence of a base. Table 1. where n is 0; m is 1; X1 is CHa, O or S; X2 is CH2 or O; Y1 is hydrogen; Y2 is an oxy group; 21 - CHA; Z is CH; R is 2-pyridyl. 2-quinolyl, 2-benzothiazolyl, 2-pyrimidinyl or 5-fluoro-2-benzothiazolyl; R 2 is phenyl, pyridyl or phenyl substituted with carboxy, methyl or methoxy. or a pharmaceutically acceptable acid addition salt thereof, or a pharmaceutically acceptable cation N 00 o CJ VI co |