http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-1775405-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7f861ceafb43f54af709c4dcc421f968 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-20 |
| filingDate | 1987-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1992-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f999c73467487adb526043f4836c56bf |
| publicationDate | 1992-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-1775405-C |
| titleOfInvention | Process for production of 2@@@-desoxynucleosid-5@@@-0-(1-thio) triphosphates |
| abstract | The invention relates to the chemistry of nucleosides, in particular to the production of 2-deoxyribonucleoside-5-0- (1-thio) triphosphates of the general formula Oe-P (0) (Oe) -0-P (0) (Oe) - 0P (SXO 0-CH2-CH-0-CHB-CH2-CH 9H, where B-adenin-9-yl or thymin-1-yl used in genetic engineering and molecular biology. The goal is to increase the yield and simplify the process. The synthesis is carried out from 2-deoxyribonucleosides by sequential treatment with phosphorus thiochloride in triethyl phosphate in the presence of pyridine at 0-5 ° C for 10-45 min, a solution of tributylammonium tetrafosphate in acetonitrile (4-10 min) and water (15-2 0 min) followed by isolation of the target substances on ion-exchange columns Yield,%; gross ph-la: a) 92; CioHi3Ll4N2Oi3 REZ: b) 92, CgHrcLMNsOnPaS. The method allows to increase the yield by more than twice, while reducing the synthesis time and consumption of reagents. Ј |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9955857-A3 |
| priorityDate | 1987-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.