| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_177bb49e57f0383c2667a5d302837034 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-135 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-49 |
| filingDate |
1988-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1995-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1e4e7aa411c0f46fa431fc50edd3d03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf4490176a84b0832eb79047f42a484f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4014e74352bdf78bb3dcbbe21dd91204
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0aa0a56901f20fcd6bc59789f41b1af3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_868f184915d27254f3d7ea23d948559e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d814db9c8c3dd3e4625ef86351048324
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0f370c12cc5777846843b6462383426
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8057fdd7ece4ae7a319ed9da087539cd |
| publicationDate |
1995-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
RU-1601978-C |
| titleOfInvention |
Method of synthesis of n-(4-bromophenyl)-n-(2-adamantyl)amine |
| abstract |
FIELD: organic chemistry. SUBSTANCE: synthesis is carried out by reaction of adamantanol with p-bromoaniline and 80-85% formic acid [molar ratio 1:(2-3):(3-4)] at boiling reaction mixture followed by distilling off formic acid excess. Reaction mass is kept at 110-130 C up to the content of unreacted adamantanone 1-2 wt.-% Then hydrochloric acid is added for hydrolysis of intermediate formamide at boiling reaction mixture, treated with sodium hydroxide aqueous solution, precipitate is separated and dissolved in isopropanol, and the product is reprecipitated. Yield is 97.3-97.8% (as compared with 80%), hydrochloride is absent (equivalent particle size is 6.16 mcm as compared with 23.72-31.28 mcm). Synthesized compounds can be used in pharmacology. EFFECT: increased yield, enhanced quality of the end product. 2 tbl |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3813817-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2547141-C1 |
| priorityDate |
1988-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |