| abstract |
SUBSTANCE: invention relates to substituted heterocyclic substances, in particular 2-aminothiazolinium salts of N-Ar or N - (- phenyl-2,3-dimethylpyrazolon-5-yl-4) cyccinamic acid, where Ag is Phenyl substituted in the p-position of SND, or in the m-position N0, which possesses analgesic 11; activity, “it can be used; used in medicine. The goal is the creation of new, more active substances of this class. Their synthesis is carried out from the corresponding L-substituted succinamic acid and 2-aminothiazoline in ethanol medium. Yield,%: mp. WITH; gross formula: a) 95.4; 129-13I; C, H, q N, 0.5; b) 95.3; 149-151; c) 98.2; 101-102; C, 5 Ng, L5045, g) 98; 159-161; C ,, H, bN405S; d) 94.4; .112-114; . An effective dose of ED is p mg / kg; toxicity, mg / kg: therapeutic index X-LD a / ZDuo: a) 50; 400 8; b) 37; 463; 12.5; c) 47; 585; 12.4; d) 44; 516; 11.7; d) 111; 906; 8.2. 3 tab. i (L C |