| abstract |
Compound of Formula (I): R is selected from optionally substituted aryl, heteroaryl, carbocyclyl and heterocyclyl groups, the optional substitution being one or more substituents selected from halo, CN, NO2, R3, OR3, N (R3) 2, COR3 , CO2R3, C (= O) SR3, SR3, S (= O) R3, SO2R3, NR4C (= O) R3, NR4CO2R3 OC (= O) NR3R4, NR4SO2R3, C (= NR4) NR3R4, C (= S) NR3R4, NR4C (= NR4) NR3R4, NR4C (= S) NR3R4, NR4C (= O) NR3R4, CONR3R4 and SO2NR3R4; 2R is an optionally substituted aromatic 8-14 membered fused bicyclic or tricyclic ring system in which one or more carbon atoms may be replaced by N, O, S, SO or SO2 and wherein the optional substitution is with one or more substituents selected from halo , CN, NO2, R3, OR3, N (R3) 2, COR3, CO2R3, C (= O) SR3, SR3, S (= O) R3, SO2R3, NR4C (= O) R3, NR4CO2R3, OC (= O) ) NR3R4, NR4SO2R3, C (= NR4) NR3R4, C (= S) NR3R4, NR4C (= NR4) NR3R4, NR4C (= S) NR3R4, NR4C (= O) NR3R4, CONR3R4 and SO2NR3R4; 3R is selected from H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 carbocyclyl, C4-C7 heterocyclyl and 5- or 6-membered aryl or heteroaryl, any of which may be optionally substituted by with one or more substituents selected from halo, CN, NO2, R4, OR4, N (R4) 2, COR4, CO2R4, C (= O) SR4, SR4, S (= O) R4, SO2R4, NR4C (= O) R4 , NR4CO2R4, OC (= O) NR4) 2, NR4SO2R4, C (= NR4) N (R4) 2, C (= S) N (R4) 2, NR4C (= NR4) N (R4) 2, NR4C (= S) N (R4) 2, NR4C (= O) N (R4) 2, CON (R4) 2 and SO2N (R4) 2; 4R is selected from hydrogen, C1-C6 alkyl and C3-C7 carbocyclyl optionally substituted by one or more halo atoms. The application contains 17 more claims. |