| abstract |
Synthesis process of ivabradine of formula (I): wherein the compound of formula (VI): is subjected to a lactamization reaction, in the presence of a coupling agent and a base, in an organic solvent to give ivabradine of formula (I), which can be transformed into its addition salts with a pharmaceutically acceptable acid selected from acids: hydrochloric, hydrobromic, sulfuric, phosphoric, acetic, trifluoroacetic, lactic, pyruvic, malonic, amber, glutaric, fumaric, tartaric, maleic, citric, ascorbic, sulfonyl, oxalic, sulfonic , as well as their hydrates. The application contains 26 more claims. |