| abstract |
A process for the preparation of cortexolone-17α-propionate in crystalline form I, wherein said crystalline form I is characterized in that the DRX spectrum is as presented in Figure 1 and that the DSC spectrum is as presented in Figure 2 and that the IR spectrum is as which is represented in Figure 3, wherein said process involves the reaction of a compound of formula II: with a compound of formula IIIR'OH (III) in the presence of a Candida lipase, where R is CH3-CH2 and R 'is a linear aliphatic chain of 1-10 carbon atoms to obtain cortexolone-17 α-propionate, and crystallization of said cortexolone-17α-propionate from tert-butyl methylether, to obtain cortexolone-17 α-propionate in crystalline form I. The application contains 22 more claims. |