http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RS-53951-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_40765ca9a78b54a8a76f781d159ad145 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-585 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4196 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 |
| filingDate | 2010-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33536fb833b8c9697dae7d4c357c3526 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db7407809dd2889df59f4f15cbc64acb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5b815dd859612398f33c513f01de5be http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0701a26bc345ddaf99f0c8589da65284 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6928d8a4792fe0dda19e4c22a6e30f07 |
| publicationDate | 2015-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RS-53951-B1 |
| titleOfInvention | KINAS INHIBITORS REGULATING SIGNAL WAYS IN APOPTOSIS |
| abstract | A compound of formula (I) wherein: R 1 is alkyl of 1-10 carbon atoms, cycloalkyl of 3-8 carbon atoms, alkenyl containing up to 10 carbon atoms, alkynyl containing up to 10 carbon atoms, aryl, heteroaryl or heterocyclyl, of which all are optionally substituted with 1, 2, or 3 substituents selected from halo, oxo, alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, heterocyclyl, phenyl, phenoxy, halo, -CN, -O-R6, -C (O) -R6, -OC (O) -R6 -C (O) -O-R6, -N (R6) -C (O) -O-R7, -N (R6) -C (O) -R7, -N (R6) -C (O) -N (R6) (R7), and -C (O) -N (R6) (R7), wherein alkyl. cycloalkyl, heterocyclyl, phenyl, and phenoxy optionally substituted with 1, 2, or 3 substituents selected from alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, alkoxy of 1 to 6 carbon atoms, hydroxyl, and halo; provided that R 1 is not methyl when R 3 is morpholinyl or furyl; wherein R6 and R7 are independently selected from the group consisting of hydrogen, alkyl of 1-6 carbon atoms, or cycloalkyl of 3-8 carbon atoms; or R 6 and R 7 when taken together with the nitrogen to which they are attached form a heterocycle, R 2 is hydrogen, halo, cyano, alkoxy, or alkyl optionally substituted with halo, R 3 is aryl, heteroaryl, or heterocyclyl, all of which are optionally substituted with 1 , 2 or 3 substituents selected from alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, halo , -CN, -O-R6, -OC (O) -R6, -OC (O) -N (R6) (R7), -S-R6, -N (R6) (R7), -S (= O) ) -R6, -S (= O) 2R6, -S (= O) 2-N (R6) (R7), -S (= O) 2-O-R6, -N (R6) -C (O) -R7, -N (R6) -C (O) -O-R7, -N (R6) -C (O) -N (R6) (R7), -C (O) -R6, -C (O) -O-R6, -C (O) -N (R6) (R7), and -N (R6) -S (= O) 2-R7, wherein alkyl, alkoxy, cycloalkyl, aryl, heteroaryl or heterocyclyl is further optionally substituted with one or more substituents selected from halo, hydroxyl, oxo, -CN, and -O-R6, provided that the heteroaryl or heterocyclyl group includes at least one nitrogen ring atom X1, X2, X3, X4, X5, X6, X7 and X8 are independently C (R4) or N, wherein each R4 is independently hydrogen, hydroxyl, halo, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, or cycloalkyl of 3 to 8 carbon atoms, wherein alkyl or cycloalkyl is further optionally substituted with one or more substituents selected from halo, hydroxyl, oxo, -CF3, -O-CF3, -N (R6) (R6) (R7), -C (O) -R6, -C (O) -O-R7, -C (O) -N (R6) (R7), -CN, -O-R6; or X5 and X6 or X6 and X7 are attached to form fused cycloalkyl, fused aryl, or fused heteroaryl, all of which are optionally substituted with alkyl of 1 to 6 carbon atoms, hydroxyl, or halo; provided that at least one of X2, X3, and X4 is C (R4), at least two of X5, X6, X7, and X8 are C (R4); at least one of X2, X3, X4, X5, X6, X7 and X8 is N. The application contains 16 more claims. |
| priorityDate | 2009-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 63.