| abstract |
A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: X is selected from -C (R 8) = or -N = wherein R 8 is hydrogen, F or CN, R 1 is selected from the group consisting of: C 1-4 alkyl, cyclopropylmethyl , cyclobutylmethyl and [1- (trifluoromethyl) cyclopropylmethyl, each of which is optionally substituted with one or more substituents as allowed by a valence independently selected from the group consisting of: F and hydroxy, R 2 is selected from hydrogen and methyl; is hydrogen then R 3 is selected from hydrogen, F or Cl, R 4 is selected from hydrogen, F or Cl, R 5 is hydrogen, R 6 is selected from hydrogen or F; and R 7 is selected from hydrogen, F or Cl, except that at least two of R 3, R 4, R 6 and R 7 must be F or Cl except when R 3 is F in which case R 4, R 6 and R 7 may all be hydrogen; and if R4 is Cl then R7 cannot be Cl; when R2 is methyl then R3 is selected from hydrogen, methyl, F, Cl, or Br; R4 is selected from hydrogen, methyl, F or Cl; R5 is selected from hydrogen or F: R6 is selected from hydrogen or F; and R 2 is selected from hydrogen, methyl, F or Cl, unless R 5 is F then at least three of R 3, R 4, R 6 and R 7 must be F; and if R4 is methyl or Cl then R7 cannot be methyl or Cl. The application contains 22 more claims. |