http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RS-53555-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a9e9ce63eb0bbf3658453fb50a6d9b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-107 |
| filingDate | 2010-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d56cfddb782818dba7e2053d85697ccd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_828e0064b188478b78ae5a23ce225dcf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_883b9e9cfde4994ad9983c1b95aa57ed http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8f8cd652891483e6fb74ecd3e0dcc64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f1e697155fc752ab353e3ceb4c96a0e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c485608534eca5d67ed1bdec00c781fb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8bf69d77c7a94c6e71c6eb401e0590dd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83feb63e7ed92d806a0910df564d60a6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e901f1b46428540019f17638449a4343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5cc1c1f495068d5d04f326d1e2de71bc |
| publicationDate | 2015-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RS-53555-B1 |
| titleOfInvention | NEW CCR2 RECEPTOR ANTAGONISTS AND THEIR APPLICATIONS |
| abstract | A compound of formula (I) wherein R1 is a group selected from -H, -halogen, -CN, -O-C1-C4-alkyl, -C1-C4-alkyl, -CH = CH2, -CECH, -CF3, - OCF3, -OCF2H, and -OCFH2; wherein R7 is a ring selected from -C3-C8-cycloalkyl, -C3-C8-heterocyclyl, -C5-C10-aryl, and -C5-C10-heteroaryl, wherein ring R7 optionally substituted by one or more groups selected from -CF3, -O-CF3, -S-CF3, -CN, -C1-C6-alkyl, -C (CH3) 2-CN, and -halogen, or wherein the ring is R7 is optionally substituted by one or more groups selected from -C1-C6-alkyl, -O-C1-C6-alkyl, -C5-C10-aryl, -C5-C10-heteroaryl, -C3-C8-cycloalkyl, -C3- C8-heterocyclyl, -C2-C6-alkenyl, and -C2-C6-alkynyl, which is optionally substituted by one or more groups selected from -OH, -NH2, -C1-C3-alkyl, -O-C1-C6- alkyl, -CN, -CF3, -OCF3, halogen, -methyl, i = O, or wherein ring R7 is optionally further bivalent substituted on two adjacent ring atoms, such that an annelation ring is formed with one or more groups selected from among -C1-C6-alkylene, -C2-C6-alkenylene and -C4-C6-alkynylene, where one or two or three carbon centers can optionally be replaced by 1 or 2 or 3 hetero atoms selected from N, O and S. a bivalent group optionally substituted by one or more groups selected from -OH, -NH2, -C1-C3-alkyl, -O-C1-C6-alkyl, -CN, -CF3, -OCF3, halogens, and = O; wherein R2 is selected from -H, -halogen, -CN, -O-C2-C4-alkyl, -C1-C4-alkyl, -CH = CH2, -C = CH, -CF3, -OCF3, -OCF2H. and -OCFH2; wherein R3 is selected from -H, -methyl, -ethyl, -propyl, -i-propyl, -cyclopropyl, -OCH3, -CF3, and in which n is 1, 2 or 3; E is independently selected from CH or N; wherein Z is C and R4 and R5 are independently selected from -H, -C1-C6-alkyl, -NH2, -C3-C8-cycloalkyl, -C3-C8-heterocyclyl. -C5-C10-aryl, -C5-C10-heteroaryl, and -C (O) -N (R8, R8 '), with R8 and R8' being independently selected from -H, and -C1-C6-alkyl. or in which Z is N and R4 denotes an electron pair and R5 is selected from -H, - C1-C6 -alkyl, -NH2, -C3-C8-cycloalkyl, -C3-C8-heterocyclyl, -C5-C10-aryl, -C5-C10-heteroaryl, and -C (O) -N (R8, R8 '), with R8 and R8 'are independently selected from -H, and -C1-C6-alkyl, and wherein R4 and R5, if different from the electron pair or -H, are optionally independently substituted by one or more groups selected from -halogens , -OH, -CF3, -CN, -C1-C6-alkyl, -O-C1-C6-alkyl, -O-C3-C8-cycloalkyl, -O-C3-C8-heterocyclyl, -O-C5-C10 -aryl, -O-C5-C10-heteroaryl, -C0-C6-alkylene-CN, -C0-C4-alkylene-O-C1-C4-alkyl, -C0-C4-alkylene-O-C3-C8-cycloalkyl , -C0-C4-alkylene-O-C3-C8-heterocyclyl, -C0-C4-alkylene-O-C5-C10-aryl, -C0-C4-alkylene-O-C5-C10-heteroaryl, -C0-C4 -alkylene-Q-C0-C4-alkyl-N (R9, R9 '), -C0-C4-alkylene-N (R10) -Q-C1-C4-alkyl, -C0-C4-alkylene-N (R10) -Q-C3-C8-cycloalkyl, -C0-C4-alkylene-N (R10) -Q-C3-C8-heterocyclyl, -C0-C4-alkylene-N (R10) -Q-C5-C10-aryl, - C0-C4-alkylene-N (R10) -Q-C5-C10-heteroaryl, -C0-C4-alkylene-QN (R11, R11 '), -C0-C4-alkylene-N (R12) -QN (R13, R13 '), -C0-C4-alkyl |
| priorityDate | 2009-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.