| abstract |
A compound having the structure I in which HET-1 is a heteroaromatic group of formula II containing from 2 to 4 nitrogen atoms: wherein Y may be N or CH, Z may be N or C, and wherein HET-1 may be optionally substituted with up to three R2-R4 substituents individually selected from hydrogen, C1-C6 alkyl; halogen; cyano, halo (C1-C6) alkyl; aryl, alkoxy and C1-C6hydroxyalkyl groups and wherein * denotes the binding site, Q represents phenyl, optionally substituted with one to five substituents, or a monocyclic 5-membered or 6-membered heteroaromatic group containing 1 or 2 heteroatoms-L- the linker is selected between -5-CH2-, -CH2-S-, -CH2-CH2-, -CH = CH- and -C≡C-R1 is selected from H, C1-C6 alkyl; C1-C6alkyl (C3-C8) cycloalkyl; C1-C6hydroxyalkyl, CH2CN, CH2C (O) NH2, C1-C6 arylalkyl, and C1-C6 alkyl-heterocycloalkyl, and tautomers and pharmaceutically acceptable salts thereof, and polymorphic forms thereof, provided that the compound is not 2- (5-phenyl- 1H-imidazol-2-ylmethylsulfanyl) -1H-benzoimidazole or 2- (5-phenyl-1H-imidazol-2-yl-sulfanyl-methyl) -1H-benzoimidazole. The application contains 14 more claims. |