| abstract |
A compound of the formula: wherein R 1 is fluorine or chlorine, Each of R 2a and R 2b is hydrogen or each is fluorine, R 3 is hydrogen, methyl, hydroxymethyl, or (C 1 -C 3) alkoxymethyl, R 4 is selected from the group consisting of fluorine, chlorine, cyano, cyanomethyl, (C1-C3) alkyl, cyclopropyl, hydroxymethyl, methoxy, cyclopropylmethoxy, aminocarbonylmethoxy, (C1-C3) alkoxymethyl, cyclopropyloxymethyl, cyclopropylmethoxymethyl, 1-hydroxy-1-methylethynymocarbonylo -NR5R6, hydroxyimine, methoxyimine, morpholin-4-yl, morpholin-4-ylmethyl, Ar1, -CH2Ar1, tetrahydrofuran-2-yl, 3-oxomorpholin-4-ylmethyl, 2-oxopyrrolidin-1-ylmethyl, and 2-oxopiperidine R5 is hydrogen, C1-C3 alkyl, cyanomethyl, -C (O) CH3, or aminocarbonylmethyl, R6 is hydrogen or methyl; Ar 1 is a residue selected from the group consisting of imidizol-1-yl, imidizol-2-yl, 2-methylimidizol-1-yl, pyrazol-1-yl, 1,2,3-triazol-1-yl; 1,2,3-triazol-2-yl; 1,2,4-triazol-1-yl, isoxazol-3-yl, oxazol-5-yl, and 3 = methyl-1,2,4-oxadiazol-5-yl; or a pharmaceutically acceptable salt thereof. The application contains 14 more claims. |