http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RS-52998-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d8dcc1ae06a665b9f19e43327bdef1ca |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4965 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4965 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 |
| filingDate | 2006-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40d2eee078e6f8cc210be22a70ec2656 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_592167e83e7e9472e45dabb165565337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_778c1ed81e6e898cfdae52f7ee54155f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_818112d9b4df2a4c10fb9da3d87b98a8 |
| publicationDate | 2014-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RS-52998-B |
| titleOfInvention | NEW PYRAZINOILGUANIDINE SODIUM CHANNEL BLOCKERS WITH PROTECTIVE "Caps" |
| abstract | Compound represented by formula (I): wherein: X is hydrogen, halogen, trifluoromethyl, C 1 -C 7 alkyl group, unsubstituted or substituted phenyl group, C 1 -C 7 alkyl-thio, phenyl-C 1 -C 7 alkyl-thio, C 1 -C 7 alkyl sulfonyl or phenyl-C1-C7 alkyl sulfonyl group, Y is hydrogen, hydroxyl group, mercapto, C1-C7alkoxy, C1-C7 alkylthio group, halogen, C1-C7 alkyl, unsubstituted or substituted phenyl group or -N (R2 R 2 is hydrogen or a C 1 -C 7 alkyl group, each R 2 is independently of one another, -R 7, - (CH 2) m -OR 8, - (CH 2) m -NR 7 R 10, - (CH 2) n (CHOR 8) (CHOR 8) ) n-CH2OR8, - (CH2CH2O) m-R8, - (CH2CH2O) m-CH2CH2NR7R10, - (CH2) n-C (O) NR7R10, - (CH2) n-Zg-R7, - (CH2) m-NR10-CH2 (CHOR8) (CHOR8) n-CH2OR8, - (CH2) n-CO2R7 or R3 and R4 are, independently of one another, hydrogen, the group represented by formula (A), C1-C7 alkyl, hydroxy C1-C7 alkyl, phenyl, phenyl-C1-C7 alkyl, (halophenyl) -C1-C7 alkyl, C1-C7- (alkylphenylacryl), C1-C7 (alkoxyphenyl) -C1-C7 alkyl, naphthyl-C1-C7 alkyl or pyridyl-C1-C7 alkyl group , provided that at least j one of the R3 and R4 groups represented by the formula (A): in which: each RL is, independently of one another, -R7, - (CH2) n-OR8, -O- (CH2) m-OR8, (CH2) n- NR7R10, -O- (CH2) m-NR7R10, - (CH2) n-CHOR8) (CHOR8) n-CH2OR8, -O- (CH2) m -CHOR8) (CHOR8) n-CH2OR8, - (CH2CH2O) m- R8, -O- (CH2CH2O) m-R8, - (CH2CH2O) m-CH2CH2NR7R10, -O- (CH2CH2O) m-CH2CH2NR7R10, - (CH2) n-C (= O) NR7R10, -O- (CH2) m-C O) NR7R10, - (CH2) n- (Z) g-R7, -O- (CH2) m- (Z) g-R7, - (CH2) n-NR10-CH2 (CHOR8) (CHOR8) n-CH2OR8 , -O- (CH2) m-NR10 -CH2 (CHOR8) (CHOR8) n-CH2OR8, - (CH2) n-CO2R7, -O- (CH2) m-CO2R7, -OSO3H, -O-glucuronide, -O-glucose, each o is, independently, an integer from 0 to 10, each p is an integer from 0 to 10, provided that the sum of o and p in each continuous chain is from 1 to 10, each x is, independently of one another , -O-, -NR10-, -C (= O) -, -CHOH-, -C (= N-R10) -, CHNR7R10- or represents a single bond, each R5 is, independently of one another, -Link- (CH2) m-CAP, -Link- (CH2) n (CHOR8) (CHOR8) n-CAP, -Link- (CH2CH2O) m-CH2-CAP, -Link- (CH2CH2O) m-CH2CH2-CAP , -Link- (CH2) m- (Z) g-CAP, -Link- (CH2) n (Z) g- (CH2) m-CAP, -Link- (CH2) n-NR13-CH2 (CHOR8) (CHOR8) n-CAP, -Link- (CH2) n- (CHOR8) mCH2-NR13- (Z) g-CAP, -Link- (CH2) nNR13- (CH2) m (CHOR8) nCH2NR13- (Z) g-CAP, -Link- (CH2) m- (Z) g- (CH2) m-CAP, -Link-NH-C (= O) -NH- (CH2) m-CAP, -Link- (CH2) m-C (= O) NR13- (CH2) m-CAP, -Link- (CH2) n- (Z) g- (CH2) m- (Z) g-CAP, or -Link-Zg- (CH2) m-Het- (CH2) m-CAP, each Link is, independently of one another, -O-, - (CH2) m-, - O (CH2) m-, -NR13-C (= O) -NR13-, -NR13-C (= O) - (CH2) m-, -C (= O) NR13- (CH2) m-, - ( CH2) n-Zg- (CH2) n, -S-, -SO-, -SO2-, -SO2NR7-, -SO2NR10- or -Het-, each CAP is, independently of one another -CR10 (- (CH2) m-R9) (- (CH2) m-R9), each Ar is, independently of one another, a phenyl group or a substituted phenyl group, wherein said substituent of the 1-3 group is independently selected from the group consisting of -OH, -OCH3 , -NR13R13, -Cl, -F and -CH3, or a heteroaryl group, wherein said heteroaryl group is selected from the group consisting of pyridine, pyrazia, tinazine, furyl, furfuryl, thienyl, tetrazole, thiazolidinedione and imidazoyl grouppyrrole, furan, thiophene, pyrides |
| priorityDate | 2005-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 70.