http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RS-52954-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_40765ca9a78b54a8a76f781d159ad145 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-706 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7052 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-23 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-23 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 |
| filingDate | 2010-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce09ad7833e765f9b715f244f0c98511 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7cea9c3484d28d4465e59561fbb18dd6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_acfbf971c4a2262c07c82f85c4cc5d13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e8a538a41f3af4dedf8832876fabe68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa0a8872685ab6f24e756d9423e612df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db4ccc55e28fb573931cd88ac3178b7d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38612ba45d4186cdedbdbf1eb4f94702 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d0557e36a3190dd7f752efe0a2c07ee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7cf4907d039cbd3621ecbadb67895d07 |
| publicationDate | 2014-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RS-52954-B |
| titleOfInvention | PROCEDURES AND INTERMEDIATES FOR THE PRODUCTION OF 1'-CYANOCARBANUCLEOSIDE ANALOGS |
| abstract | A process for the production of a compound of Formula I: or an acceptable salt thereof; where: R1 is H, (C1-C8)alkyl, (C4-C8)carbocyclylalkyl, (C1-C8)substituted alkyl, (C2-C8)alkenyl, (C2-C8)substituted alkenyl, (C2-C8)alkynyl, (C2-C8)substituted alkynyl, or aryl(C1-C8)alkyl; each R2a or R2b is independently H, F or OR4; each R3 is independently (C1-C8)alkyl, (C1-C8)substituted alkyl, C6-C20 aryl, C6-C20 substituted aryl, C2-C20 heterocyclyl, C2-C20 substituted heterocyclyl, C 7 -C 20 arylalkyl, C 7 -C 20 substituted arylalkyl, (C 1 -C 8 ) alkoxy, or (C 1 -C 8 ) substituted alkoxy; each R4 or R7 is independently H, optionally substituted allyl, -C(R5)2R6, Si(R3)3, C(O)R5, C(O)OR5, -(C(R5)2)m-R15 or either which two R4 or R7 together are -C(R19)2-, -C(O)- or -Si(R3)2(X2)mSi(R3)2-; each R15 is independently -O-C(R5)2R6, -Si(R3)3, C(O)OR5, -OC(O)R5 or each R5, R18 or R19 is independently H, (C1-C8) alkyl, (C1- C8) substituted alkyl, (C2-C8)alkenyl, (C2-C8) substituted alkenyl, (C2-C8) alkynyl, (C2-C8) substituted alkynyl, C6-C20 aryl, C6-C20 substituted aryl, C2-C20 heterocyclyl , C2-C20 substituted heterocyclyl, C7-C20 arylalkyl or C7-C20 substituted arylalkyl; each R6 is independently C6-C20 aryl, C6-C20 substituted aryl, or optionally substituted heteroaryl; each Ra is independently H, (C1-C8)alkyl , (C2-C8)alkenyl, (C2-C8)alkynyl, aryl(C1-C8)alkyl, (C4-C8)carbocyclylalkyl, -C(=O)R11, -C(=O)OR11, -C(= O)NR11R12, -C(=O)SR11, -S(O)R11, -S(O)2R11, -S(O)(OR11), -S(O)2(OR11) or -SO2NR11R12; X1 is C-R10 or N; each X2 is O or CH2; each m is 1 or 2; each n is independently 0, 1 or 2; each R8 is halogen, NR11R12, N(R11)OR11, NR11NR11R12, N3, NO, NO2 , CHO, CH(=NR11), -CH=NHNR11, -CH=N(OR11), -CH(OR11)2, -C(=O)NR11R12, -C(=S) NR11R12, -C(-O )OR11, (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8) alkynyl, (C4-C8)carbocyclylalkyl, optionally substituted aryl, optionally substituted heteroaryl, -C(=O)(C1-C8)alkyl, -S(O)n(C1-C8)alkyl, aryl(C1-C8)alkyl , CN, OR11 or SR11; each R9 or R10 is independently H, halogen, NR11R12, N(R11)OR11, N(R11)N(R11)(R12), N3, NO, NO2, CHO, CN, -CH( =NR11), -CH=NNH(R11), -CH=N(OR11), -CH(OR11)2, -C(=O)NR11R12, -C(=S)NR11R12, -C(=O)OR11 , R11, OR11 or SR11; each R11 or R12 is independently H, (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C3-C8)carbocyclyl, (C4-C8)carbocyclylalkyl, optionally substituted aryl, optionally substituted heteroaryl , -C(=O)(C1-C8)alkyl, -S(O)n(C1-C8)alkyl, aryl(C1-C8)alkyl or Si(R3)3; or R11 and R12 together with the nitrogen to which they are both attached form a 3- to 7-membered heterocyclic ring in which any carbon atom of said heterocyclic ring can optionally be replaced by -O-, -S(O)n- or -NRa-; or R11 and R12 together are -Si(R3)2(X2)mSi(R3)2-; each R 20 is independently H, (C 1 -C 8 )alkyl, substituted (C 1 -C 8 )alkyl or halo; wherein each (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl or aryl(C1-C8)alkyl in each R1, R3, R4, R5, R6 R18 R19, R20, R11 or R12 is, independently, optionally substituted with one or more halo, hydroxy, CN, N3, N(Ra)2 or ORa; and wherein one or |
| priorityDate | 2009-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 34.