| abstract |
A compound of formula I: or a single stereoisomer or mixture of stereoisomers and optionally as a pharmaceutically acceptable salt or solvate thereof, wherein R 1 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aryl, substituted substituted aryl substituted heterocycloalkylalkyl, optionally substituted heteroaryl or optionally substituted heteroarylalkyl, R2 is hydrogen or alkyl, wherein alkyl is optionally substituted with 1, 2, 3, 4 or 5 R8 groups, X is -NR3-, R3 is hydrogen, R4 is optionally substituted alkyl R5 is hydrogen; R 6 is phenyl, acyl, or heteroaryl, wherein the phenyl and heteroaryl are optionally substituted with 1, 2, 3, 4 or 5 R 9 groups, each R 8, when present, is independently hydroxy, halo, alkoxy, haloalkoxy, amino, alkylamino, dialkylaminoalkyl or alkoxyalkylamino; however R9, when present, is independently halo, alkyl, haloalkyl, alkoxy, haloalkoxy, cyano, amino, alkylamino, dialkylamino, alkoxyalkyl, carboxyalkyl, alkoxycarbonyl, aminoalkyl, cycloalkyl, aryl, arylalkyl, aryloxy, heterocyclo aryl, heterocycloalkyl and heteroaryl, each individually or as part of another group within R9, are independently optionally substituted with 1, 2, 3 or 4 groups selected from halo, alkyl, haloalkyl, hydroxy, alkoxy, haloalkoxy, amino, alkylamino and dialkylamino. contains another 53 patent claims. |