http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RS-52759-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_938a6d7a15cbc93a74abe1953eb25d47 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-433 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-74 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 |
| filingDate | 2008-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e596a9b7b5034d1a97b85da1cadc89dc |
| publicationDate | 2013-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RS-52759-B |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF CYCLOalkylcarboxyamide-benzoic acids |
| abstract | Process for the preparation of Compound 1: comprising the steps of: i) providing 2-bromo-3-methylpyridine (Compound 2) and 3- (t-butoxycarbonyl) phenylboronic acid (Compound 3), ii) Cross coupling of Compound 2 and Compound 3 in biphasic a mixture consisting of water, a first organic solvent, a first base, and a transition metal catalyst to give compound 4, iii) oxidation of compound 4 to give compound 5, and iv) adding an amino group to position 6 of the pyridyl residue at to give compound 6, c) reacting compound 6 with compound 7 in a second organic solvent in the presence of a second base to give compound 8, vi) de-esterifying compound 8 in a biphasic mixture consisting of water, a third organic solvent. and first acids to give compound 9, and iii) suspending or dissolving compound 9 in a suitable solvent over an effective period of time to give compound 1. The application further comprises 32 claims. |
| priorityDate | 2007-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.