| abstract |
Compounds according to Formula (I) or a pharmaceutically acceptable salt or solution thereof, wherein V is -N (R 1 X R 2); R 1 and R 2 are each independently L 1, in which L 1 is selected from the groups containing H, C 1-6 alkyl, C 2-6 alkenyl. C2-6alkynyl, -C1-6alkylene-amino (C1-3alkyl) 2, C3-7cycloalkyl, phenyl, azetidinyl, adamantyl, tetrahydrofuranyl, furanyl, dioxolanyl, thienyl, tetrahydrothienyl, pyrrolyl, pyrrolinyl, pyrrolidinyl, imidazolinyl, imidazolinyl, imidazolinyl, imidazolinyl, imidazolinyl , pyrazolinyl, pyrazolidinyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, oxadiazolyl, thiadiazolyl, triazolyl, pyranyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, triazinyl, piperidinyl, piperazinyl, piperazinyl, piperazinyl, piperazinyl, piperazinyl, piperazinyl substituted with 1 or 2 of the same or different substituents selected from the group consisting of halo, cyano, C1-4alkyl, C1-4haloalkyl, C1-4alkoxy, hydroxy, amino, C3-7cycloalkyl, C1-3alkylamino, C1-3dialkylamino, (C1-3alkyl) ) 0-2ureido, phenyl and benzyl; and R 1 and R 2 optionally and independently contain 1 or 2 carbonyls in which the carbon atom of said carbonyl is a member of heterocyclic rings including R 1 and R 2; C1-3alkylidene; or R 1 and R 2 together with the nitrogen together with which they form X, wherein X is azetidinyl, pyrrolyl, pyrrolinyl, pyrrolidinyl, imidazolyl, imidazolidinyl, pyrazolinyl, pyrazolidinyl, azepinyl, diazepinyl, piperazinyl, piperidinyl, morpholino or thiomorpholino, or thiomorpholino; Y, where Y is dioxolanyl, C 1-9 alkyl, C 2-9 alkenyl, C 2-9 alkynyl, C 1-4 alkylamino, C 1-4 dialkylamino, C 1-4 alkoxy, C 3-7 cycloalkyl, phenyl, azetidinyl, furanyl, thienyl, pyrrolyl, pyrrolinyl, pyrrolidinyl, pyrrolidinyl , imidazolyl, imidazolinyl, imidazolidinyl, imidazolidinonyl, pyrazolyl, pyrazolinyl, pyrazolidinyl, azepinyl, diazepinyl, pyridyl, pyrimidinyl, dihydrobenzimidazolonyl, piperazinyl, piperidinyl, morpholinyl, piperidinyl, morpholinyl, piperidinyl, morpholinol Z -NHC (O) O-, -NHC (O) NH-, NC (O) NH2, -NH-, -C1-3alkylene, -C1-3alkylene-, -C1-3-alkenylene-NHC (O) O -C1-3alkylene-; optionally and independently substituted with 1 or 2 of the same or different substituents selected from the group consisting of C1-4alkyl, amino, C1-3alkylamino, -C1-6alkylene-amino (C1-3alkyl) 2, (C1-3alkyl) 0-2ureido , phenyl and benzyl; X and Y optionally and independently contain 1 or 2 carbonyls where the carbon atom of said carbonyl is a member of the heterocycle including X and Y; if it is ensured that X is substituted with Y, or if X and Y are not interrupted by Z, then X and Y optionally share one carbon atom and together form a polycyclic moiety Q is Q '; where Q 'is (Sy) sR 3; where Sy is C1-3alkylene or C1-3alkylidene and is 0 or 1; U is CH2 or NH; R3 is R3a or R3b where R3a is indazolyl; or R3a is optionally substituted with 1 to 3 same or different substituents selected from benzyl, phenyl-containing groups , -O-phenyl, -O-C1-3alkyl |