| abstract |
A compound of formula (IV) where U represents: and in which (a) R1 and R3 represent methyl or ethyl; where R2 can be H, methyl, ethyl, chloromethyl, dichloromethyl or trifluoromethyl; where R4 is C1-C4 alkyl; C3-C7 cycloalkyl; C3-C7 cycloalkyl-C1-C7 alkyl; phenyl-C1-C7 alkyl or aryl; where R5 represents H; and U has a structure of formula II in which X represents N; where R6, R6', R7 and R'7 can be H; or R6 represents -C(O)-C1-C4 alkyl-phenyl and where R6', R7 and R'7 represent H; n is 0, so (Ra)n and (Rb)n both denote a bond; Rc represents H; Rd represents Ar1-D-Ar2, wherein Ar1 and Ar2 are substituted and unsubstituted phenyl or het; and where D is N(Rh) , when Rh represents H, Me, -CHO, -SO2, -C(O), -CHOH, -CF3 or - SO2CH3; or where(b) R1 and R3 represent methyl or ethyl; when R2 represents H, methyl, ethyl , chloromethyl, dichloromethyl or trifluoromethyl; where R4 can be C1-C4 alkyl; C3-C7 cycloalkyl; C3-C7 cycloalkyl-C1-C7 alkyl; fen¬el alkyl or aryl; where R5 represents H; U has a structure of formula II in which X represents N; where R6, R6', R7 and R'7 can be H; n is 0, so that (Ra)n and (Rb )n both represent a bond; Rc represents H; Rd represents Ar1-D-Ar2, wherein Ar1 and Ar2 are substituted and unsubstituted phenyl or het; and D is -O-; or where (c) R1 and R3 represent methyl or ethyl; when R2 represents H, methyl, ethyl, chloromethyl, dichloromethyl or trifluoromethyl; where R4 can be C1-C4 alkyl; C3-C7 cycloalkyl; where R5 represents H; where U has a structure of formula II in which X represents N; where R6, R6', R7 and R'7 represent H; n is 0, so that (Ra)n and (Rb)n both denote a bond; where Rc represents H; Rd represents Ar1-D-Ar2, where Ar1 and Ar2 are substituted and unsubstituted phenyl or het; and D is C(O)-; where "het" can be a 5-membered to 7-membered heterocyclic ring containing 1-4 ring heteroatoms selected from N, O and S or 8-membered to 12-membered fused ring comprising a 5-membered to 7-membered monocyclic heterocyclic ring containing 1, 2 or 3 ring heteroatoms selected from N, O and S, wherein said heterocyclic ring or fused ring system may be unsubstituted or substituted at the carbon atom or nitrogen, or a pharmaceutically acceptable salt thereof. The application contains 17 more patent claims. |