http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RS-52528-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c89ce4d9ac03f9acd8ddede1162f94d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C53-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C53-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C57-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 |
| filingDate | 2009-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_44e52c692bbdd2018dad0315b20e0609 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26bd93251cfc5ac5a578d5849529849d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b074e34f24c16039b563836ad865805 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de6edf18f464dd7b582ffc2b822e5773 |
| publicationDate | 2013-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RS-52528-B |
| titleOfInvention | ARYL METHYL BENZOHINAZOLINONE AS POSITIVE M1 RECEPTOR MODULATORS |
| abstract | A compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein each of X, Y and Z is CH and Q is C, or one of X, Y, Q and Z is N and the other is CH or C, or X and Y are CH and Q, R 1 and Z are bonded together to form a naphthyl group; R1 is selected from the group consisting of (1) hydrogen, (2) aryl, (3) a heteroaryl group which is a cyclic or polycyclic group having from five to twelve ring atoms, wherein said atoms are selected from C, O, N or S, wherein at least one of them is O, N or S, (4) halogen, (5) -CN, (6) -O-C1-6 alkyl, (7) -C1-6 alkyl, (8 ) -C2-6 alkenyl (9) -S(=O)n-R4, (10) -NR5AR5B, wherein the specified aryl, heteroaryl, alkyl and alkenyl group is optionally substituted with one or more halogens, (b ) hydroxy, (c) -O-C1-6 alkyl, (d) -C1-6 alkyl, (e) -C(=O)-(O)m-R6, (f) -N(R5AR5B), ( g) -S(=O)n-R8, or(h) oxo, with the proviso that when Q equals N, then R1 is absent; R is selected from the group consisting of (1) hydrogen, (2) aryl, ( 3) a heteroaryl group which is a cyclic or polycyclic group, having from five to twelve atoms in the ring, wherein said atoms are selected from C, O, N or S, wherein at least one of them is O, N or S, ( 4) heterocyclic group, which is a non-aromatic cyclic or polycyclic group having from five to twelve st atoms in the ring selected from C, O, N or S, wherein at least one of them is O, N or S, (5) -O-C1-6 alkyl, (6) -C1-6 alkyl, (7) -C2-6 alkenyl, (8) -S(=O)n-R4, (9) -C3-8 cycloalkyl, (10) -C5-8 cycloalkenyl, (11) -NR5AR5B, wherein aryl, heteroaryl , heterocyclyl, alkyl, alkenyl, cycloalkyl and cycloalkenyl group optionally substituted with one or more (a) halogen, (b) hydroxy, (c) -O-C1-6 alkyl, (d) -C1-6 alkyl, (e) -S(=O)n-R8,(f) -C2-6 alkenyl,(g) -CN,(h) -C(=O)-(O)m-R6,(i) -NR5AR5B,(j ) oxo, (k) aryl, (l) heteroaryl group which is a cyclic or polycyclic group, having from five to twelve ring atoms, wherein said atoms are selected from C, O, N or S, wherein at least one is of which O, N or S,(m) a heterocyclic group, which is a non-aromatic cyclic or polycyclic group having from five to twelve ring atoms selected from C, O, N or S, at least one of which is O, N or S(n) -OC(=O)- R6, wherein is an alkyl, alkenyl, aryl, heteroaryl or heterocyclic group and collectively substituted with one or more (i) halogen, (ii) -C1-6 alkyl, or (iii) -OC1-6 alkyl; R3 is selected from the group consisting of (1) hydrogen, (2) -C1-6 alkyl , and (3) -S(O)n-R4, wherein said R3 alkyl group is optionally substituted with one or more (a) halogen, (b) cyano, and (c) -O-C1-6 alkyl, wherein said alkyl is optionally substituted with one or more halo; R4, R6 and R8 are independently selected from the group consisting of (1) hydrogen, (2) -C1-6 alkyl, and (3) -(CH2)n-aryl , wherein said R4, R6 or R8 is an alkyl or aryl group optionally substituted with one or more of (a) halogen, (b) cyano, and (c) -O-C1-6 alkyl, wherein said alkyl is optionally substituted with by one or more halogens; R5A and R5B are selected from the group consisting of (1) lead |
| priorityDate | 2008-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 43.