http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RS-52483-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_938a6d7a15cbc93a74abe1953eb25d47 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65515 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65844 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-265 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-341 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-655 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-215 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6584 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-665 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-664 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-661 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-20 |
| filingDate | 1998-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9fe739815c66d2a86bf5761df1dfdf2d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89ca95c2918fc8ad2edd5019429c4553 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d13d288f92ec5cc8045b584dc19a287f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6d9178cd6bde27e09ba6e2c16d7ccb3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53cfb3367cb48548bd9b1ee54a2e7732 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5819fb765ae190c26bebce15419649f2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7bf4c1e1cad147796d575e3e9d70392d |
| publicationDate | 2013-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RS-52483-B |
| titleOfInvention | SULFONAMIDE DERIVATIVES AS ASPARTYL PROTEASE INHIBITOR PRO-DRUGS |
| abstract | Compound of Formula: A is selected from H; Ht; -R1-Ht; -R1- (C1-C6) -alkyl, which is optionally substituted by one or more groups independently selected from hydroxy, C1-C4 alkoxy, Ht, -O-Ht, -NR2-CO-N (R2) 2 or -CO -N (R 2) 2; -R1- (C2-C6) -alkenyl, which is optionally substituted by one or more groups independently selected from hydroxy, C1-C4 alkoxy, Ht, -O-Ht, -N (R2) -C (O) -N ( R2) 2 or -CO-N (R2) 2; or R7; each R1 is independently selected from -C (O) -, -S (O) 2-, -C (O) -C (O) -, -OC (O) -, -OS (O) 2, -N (R2) -S (O) 2-, -N (R2) - (O) - or -N (R2) -C (O) -C (O) -; each Ht is independently selected from C3-C7 cycloalkyl; C5-C7 cycloalkenyl; C6-C10 aryl; or 5-7 membered saturated or unsaturated heterocycle containing one or more heteroatoms selected from N, N (R2), O, S and S (O) n; wherein said aryl or said heterocycle is optionally fused to Q; And where any member of said Ht is optionally substituted with one or more substituents independently selected from oxo, -OR2, -SR2, -R2, -N (R2) 2, -R2-0H, -CN, -C (O) O -R2, -C (O) -N (R2) 2, -S (O) 2-N (R2) 2, -N (R2) -C (O) -R2, -C (O) -R2, - S (O) n-R2, -OCF3, -S (O) nQ, methylenedioxy, -N (R2) -S (O) 2-R2, halo, -CF3, -NO2, Q, -OQ, -OR7. -SR7, -R7, -N (R2) (R7) or -N (R7) 2; each R2 is independently selected from H, or (C1-C4) -alkyl optionally substituted by Q; B, when present, is -N (R2) -C (R3) 2-C (O) -; each x is independently 0 or 1; each R3 is independently selected from H, Ht, (C1-C6) -alkyl, (C2-C6) - alkenyl, (C3-C6) -cycloalkyl or (C5-C6) -cycloalkenyl; wherein any member of said R3 other than H is optionally substituted by one or more substituents selected from -OR2, -C (O) -NH-R2, -S (O) nN (R2) 2, Ht, -CN, - SR2, -CO2R2, -N (R2) -C (O) -R2; each n is independently 1 or 2; G, when present, is selected from H, R7 or (C1-C4) -alkyl, or, when is G (C1-C4) -alkyl, G and R7 are attached to each other either directly or through a C1-C3 bond to form a heterocyclic ring; or when G is not present, the atom to which G is attached is attached directly to the R7 group in -OR7 with the subsequent displacement of one -ZM group from R7; D and D 'are independently selected from Q; (C1-C6) -alkyl, which is optionally substituted by one or more groups selected from (C3-C6) -cycloalkyl, -OR2, -R3, -O-Q or Q; (C2-C4) -alkenyl, which is optionally substituted by one or more groups selected from (C3-C6) -cycloalkyl, -OR2, -R3, -O-Q or Q; (C3-C6) -cycloalkyl, which is optionally substituted with or fused to Q; or (C5-C6) -cycloalkenyl, which is optionally substituted with or fused to Q; each Q is independently selected from a 3-7 membered saturated, partially saturated or unsaturated carbocyclic ring system; or a 5-7 membered saturated, partially saturated or unsaturated heterocyclic ring containing one or more heteroatoms selected from O, N, S, S (O) n or N (R2); wherein any ring in Q is optionally substituted by one or more groups selected from oxo, -OR2, -R2, -N (R2) 2, -N (R2) -C (O) -R2, -R2-OH, - CN, -C (O) OR2, -C (O) -N (R2) 2, halo or -CF3; E |
| priorityDate | 1997-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID458397310 |
Total number of triples: 57.