http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RS-52376-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_28e3113097dd6d28720572e47f2f2407 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4184 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4245 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4245 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 |
| filingDate | 2005-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_345461d16c68add724ddf8f6c0db58ad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0eb8ebd7cc93ab4bf439bfd097a10419 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de8d095dfb1ede6bb9b4e60a2f53713a |
| publicationDate | 2012-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RS-52376-B |
| titleOfInvention | BENZIMIDAZOL DERIVATIVES AND ITS USE AS AN ALL-RECEPTOR ANTAGONISTS |
| abstract | A process for preparing a compound of formula (I): wherein R 1 is a group represented by the formula: wherein each of R 2, R 3, R 4, R 5, R 6, R 7 and R 8 is independently a hydrogen atom or C 1-6 alkyl, or a salt thereof, comprising the following steps: (1) reacting a compound of formula (II): or a salt thereof, with an acylating reagent (III): wherein X is a halogen atom and R 12 is alkyl, alkoxy or phenyl optionally substituted by a halogen atom, a C 1-6 alkyl or nitro group , in the presence of a base to give a mixture of acid anhydride and the reaction of a mixture of acid anhydride with alcohol (IV): HO-R1 (IV) wherein R1 is as previously defined, in the presence of a base allowing esterification, (2) the reaction of a compound of formula (II): or salts thereof, with thionyl chloride or oxalyl chloride in the presence of a catalyst to give the acid chloride, and then reacting the acid chloride with an alcohol (IV): HO-R1 (IV) wherein R1 is as previously defined, in the presence of a base to allow esterification, (3) reacting a compound of formula (II): or a s oli, with an alkylating agent (V): X '-R1 (V) wherein X' is a halogen atom and R1 is as previously defined, optionally in the presence of a base to allow esterification, or (4) the reaction of a compound of formula (II): or salts thereof, with an alcohol (IV): HO-R1 (IV) wherein R1 is as previously defined, in the presence of a condensing agent to allow esterification. The application contains a further 8 claims. |
| priorityDate | 2004-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.