http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RS-52172-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6572ff5df928fd17340eb2a8cb6d8502 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e9010f8ae7c32e8b62cd768952bf535 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D281-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D281-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D281-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D281-08 |
| filingDate | 2009-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca1ee656b7d5fb76dbeff34e7c225014 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c889c9ea90b3da80030cebd05c9bcca8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_add096c66ca39d1150e569ab2acf37c0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e835891e48c90283238a0a0a2c59d07 |
| publicationDate | 2012-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RS-52172-B |
| titleOfInvention | PROCEDURE FOR THE PRODUCTION OF BENZOTHIAZEPINE FROM GAMA-AMINOALKYLBENZENE |
| abstract | Process for the production of 2,3,4,5-tetrahydro[1,4]benzothiazepine, which has the formula: comprising the reaction of $2-(acylaminoethyl)thio]arene of the formula: with an aldehyde of the formula R4CHO or its multimer and with an acid, wherein: Ar is a monocyclic, bicyclic or tricyclic aryl or heteroaryl ring system; R1 , R2 and R4 are, each independently, H, (C1-C20)hydrocarbon, (C1-C6)alkyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, ( C1-C6)alkyl-aryl, (C1-C6)alkyl-cycloalkyl, (C1-C6)alkyl-heterocyclyl or (C1-C6)alkyl-heteroaryl, wherein each of aryl, cycloalkyl, heterocyclyl and heteroaryl is optionally substituted with with one to three substituents, which are independently selected from the group consisting of: halogen, alkyl, alkoxy, nitro, cyano and haloalkyl; R3 is (C1-C10)acyl; P(O)R8R9, C(=O)-R10, C(=S)-R11, S(=O)2R12, (CH2)mR13, nitrogen protecting group, OH, (C1-C6)alkyl, cycloalkyl, aryl , heterocyclyl, heteroaryl, (C1-C6)alkyl-aryl, (C1-C6)alkyl-cycloalkyl, (C1-C6)alkyl-heterocyclyl or (C1-C6)alkylheteroaryl, wherein each of aryl, cycloalkyl, heterocyclyl and heteroaryl optionally substituted with one to three substituents independently selected from the group consisting of: halogen, alkyl, alkoxy, nitro, cyano and haloalkyl; or, taken together, R2 and R3 form a nitrogen-containing oxo-substituted heterocycle; R5 is, independently, in each of its occurrences: H, (C1-C20)hydrocarbon, (C1-C6)alkyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, (C1-C6)alkyl-aryl, (C1-C6)alkyl-cycloalkyl, (C1-C6)alkyl-heterocyclyl or (C1-C6)alkyl-heteroaryl, halogen, acyl, SO3, -OR6, -SR6, -NR6aR6b, -N(R6)C(=O)OR7, N(R6)C(=O)R7, -C(=O)NR6aR6b, -C(=O)OR6, -C(=O)R6, -OC(=O)R6, -NO2, -CN, -(C1-C6)haloalkyl, -O-(C1-C6)haloalkyl, -N3 or -P(O)R8R9, each of which is aryl, cycloalkyl , heterocyclyl and heteroaryl optionally substituted with one to three substituents, which are independently selected from the group consisting of: halogen, alkyl, alkoxy, nitro, cyano and haloalkyl; R10 and R11 are each, independently: H, -OR14, -NR6aR6b, NHNHR15 , NHOH, CONH2NHR15, CO2R15, CONR15, halogen, alkoxy, aryloxy, allyloxy, benzyloxy, substituted benzyloxy, fluoroenylmethoxy, adamantyloxy, (C1-C20)hydrocarbon, (C1-C6)alkyl, cycloalkyl, aryl, heteroc cyclyl, heteroaryl, (C1-C6)alkyl-aryl, (C1-C6)alkyl-cycloalkyl, (C1-C6)alkyl-heterocyclyl or (C1-C6)alkyl-heteroaryl, wherein each of aryl, cycloalkyl, heterocyclyl and heteroaryl optionally substituted with one to three substituents, which are independently selected from the group consisting of: halogen, alkyl, alkoxy, nitro, cyano and haloalkyl; R6, R6a, R6b, R7, R8, R9, R12, R14, R15, R16 and R17 are each, independently, in each of their occurrences: H, -OR15, -NR15R16, NHNHR16, NHOH, (C1-C20)hydrocarbon, (C1-C6)alkyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, (C1- C6)alkyl-aryl, (C1-C6)alkyl-cycloalkyl, (C1-C6)alkyl-heterocyclyl or (C1-C6)alkyl-heteroaryl, wherein each of aryl, cycloalkyl, heterocyclyl and heteroaryl is optionally substituted |
| priorityDate | 2008-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.