| abstract |
Compound of Formula (I): wherein R 1 is C 3-8 alkyl, C 3-8 alkenyl, C 3-8 cycloalkyl, (C 3-8 cycloalkyl) C 1-6 alkyl, (C 3-8 cycloalkyl) C 3-8 alkenyl or (C 1-8 alkylcarbonyl) C 1-8 alkyl; n is 1 or 2; X is O or S; one of R2, R3 and R4 is G and the other two are independently hydrogen, fluoro, chloro, bromo, nitro, trifluoromethyl, methyl or C1-3alkoxy; G is LQ; L is non-branched - (CH 2) m -, where m is an integer from 1 to 7; Q is NR 8 R 9, where R 8 is independently selected from hydrogen, C 1-6 alkyl, C 3-6 alkenyl, 3- to 9-membered carbocyclyl, 3- to 12-membered heterocyclyl, phenyl, (6- to 9-membered heterocyclyl) C 1-6 alkylene and (phenyl) C 1-6 alkylene; and R 9 is independently selected from C 1-6 alkyl, C 3-6 alkenyl, 6- to 9-membered carbocyclyl, 3- to 12-membered heterocyclyl, phenyl, (6- to 9-membered heterocyclyl) C 1-6 alkylene and (phenyl) C 1-6 6alkylene; or Q represents a saturated 3- to 12-membered via N-linked heterocyclyl, wherein in addition to the N-linked nitrogen, this 3- to 12-membered heterocyclyl may optionally contain between 1 and 3 heteroatoms independently selected from O, S and NH; wherein Q is optionally substituted with 1-3 substituents independently selected from the group consisting of hydroxy, halo, carboxamide, C1-6alkyl, 5- to 9-membered or 6- to 9-membered heterocyclyl, -N (C1- 6alkyl) (5- to 9-membered or 6- to 9-membered heterocyclyl), -NH (5- to 9-membered or 6- to 9-membered heterocyclyl), -O (5- to 9-membered or 6- to 9-membered heterocyclyl), (5- to 9-membered or 6- to 9-membered heterocyclyl) C1-3alkylene, C1-6alkoxy, (C3-6cycloalkyl) -O-, phenyl, (phenyl) C1-3alkylene and ( phenyl) C1-3alkylene-O-, wherein each of the above heterocyclyl, phenyl and alkyl groups may be optionally substituted with from 1 to 3 substituents independently selected from trifluoromethyl, methoxy, halo, nitro, cyano, hydroxy and C1-3alkyl; and wherein each of the above alkyl, alkylene, alkenyl, heterocyclyl, cycloalkyl, carbocyclyl and aryl groups may be independently and optionally substituted with from 1 to 3 substituents independently selected from trifluoromethyl, methoxy, halo, amino, nitro, hydroxy and C1 Or a pharmaceutically acceptable salt, ester, tautomer, solvate or amide thereof. The application contains a further 54 claims. |