| abstract |
A compound having formula (I) or a stereochemically isomeric form thereof, wherein R 1 is C 1-6 alkyl; or C1-3alkyl substituted with C3-7cycloalkyl, phenyl or phenyl substituted with halo, trifluoromethyl or trifluoromethoxy, R2 is halo, trifluoromethyl, C1-3alkyl or cyclopropyl, R3 is hydrogen, fluoro, hydroxyl, hydroxyC1-3alkyl, hydroxyC1-3alkyl -3alkyl, fluoroC1-3alkoxy or cyano; and Ar is unsubstituted phenyl; or phenyl substituted with n radicals R4, wherein n is 1, 2 or 3. R4 is selected from the group consisting of hydrogen, halo, C1-3alkyl, hydroxyC1-3alkyl, polyhaloC1-3alkyl, cyano, hydroxyl, amino, carboxyl, C1- 3alkyloxyC1-3alkyl, C1-3alkyloxy, polyhaloC1-3alkyloxy, C1-3alkylcarbonyl, mono- and di (C1-3alkyl) amino and morpholinyl; or two vicinal R4 radicals taken together form a bivalent radical of formula-N = CH-NH- (a), -CH = CH-NH- (b), or -O-CH2-CH2-NH- (c); or the R3 and R4 radicals in ortho positions taken together form a bivalent radical of formula-CH2O- (d), or -O-CH2- (e); or a pharmaceutically acceptable salt or solvate thereof. For the treatment of bipolar disorder. The application comprises 11 further claims. |