| abstract |
Compounds of formula (I): wherein: A is O, CH 2, S, SO or SO 2, X and Y are each independently selected from the group consisting of Br, Cl and -CH 3; R 1 is selected from the group consisting of: - (CH 2) n COOH, - OCH 2 COOH, - NHC (= O) COOH, - NHCH 2 COOH, Z is H, and N is -C≡N, R 2 is lower alkyl, R 3 is H or lower alkyl n is 1, 2 or 3; p is 1 or 2, or a pharmaceutically acceptable salt or ester thereof, wherein "lower alkyl" is branched or unbranched, cyclic or acyclic, saturated or unsaturated hydrocarbyl group wherein the lower is a cyclic alkyl group, C5, C6 or C7, and wherein is a lower acyclic alkyl group, C1, C2, C3, C4, C5, or C6. The application contains 26 other dependent claims. |