http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RS-51547-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1e98e0ae3d75be6b8624b5f45b037604 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-426 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-421 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-421 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-426 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-32 |
| filingDate | 2006-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d4ae98b6b73a7b95edd46bec78fb115 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f131276bef7f203930075c928fa7c257 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74eb2f49537245ccaba431c7d95cfab8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8ecd11c5babc2e03f2b6acdd6186780 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_732201099a209ca15253d9a90bb43ff0 |
| publicationDate | 2011-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RS-51547-B |
| titleOfInvention | AZOL AND THIAZOL DERIVATIVES AND THEIR USE |
| abstract | Compound of Formula (I): (i) R 1 is C 1 -C 6 alkyl or hydrogen; and R 2 is hydrogen or a group -R 7, -Z-Y-R 7, -Z-NR 9 R 10; -Z-CO-NR 9 R 10, -Z-NR 9 -C (O) O-R 7, or -Z-C (O) -R 7; and R3 is an unpaired pair or C1-C6 alkyl; or (ii) R1 and R3 together with the nitrogen to which they are attached form a heterocycloalkyl ring, and R2 is an unpaired pair or group -R7, -ZY-R7, -Z-NR9A10, -Z-CO-NR9R10, -Z-NR9- C (O) O-R7; or -Z-C (O) -R7; or (iii) R1 and R2 together with the nitrogen to which they are attached form a heterocycloalkyl ring, said ring optionally substituted with the group -Y-R7, -Z-Y-R7, -Z-NR9R10; -Z-CO-NR 9 R 10; -Z-NR 9 -C (O) O-R 7; or -Z-C (O) -R7; and R3 is an unpaired pair or C1-C5 alkyl; combinations of R4 and R5 are those wherein (i) each of R4 and R5 is a monocyclic heteroaryl of 5 or 6 ring atoms; (ii) each of R4 and R5 is phenyl; (iii) one of R4 and R5 is phenyl and the other is cycloalkyl; and (iv) one of R4 and R5 is a monocyclic heteroaryl of 5 or 6 ring atoms and the other is cycloalkyl; R6 is -OH, C1-C6-alkyl, C1-C6-alkoxy, hydroxy-C1-C6-alkyl, nitrile , group CONR82 or hydrogen atom; A is oxygen or sulfur atom; X is alkylene, alkenylene or alkynylene group; R7 is C1-C6 alkyl, aryl, aryl-fused to cycloalkyl, aryl-fused to-heterocycloalkyl, heteroaryl, aryl A (C1-C6-alkyl) -, heteroaryl (C1-C6-alkyl) -, cycloalkyl or heterocycloalkyl group; R8 is a C1-C6-alkyl or hydrogen atom; Z is a C1-C16-alkylene, C2-C16-alkenylene or a C2-C16-alkynylene group; Y is a bond or an oxygen atom; R 9 and R 10 are independently a hydrogen atom, C 1 -C 6 alkyl, aryl, aryl-fused to-heterocycloalkyl, aryl-fused to cycloalkyl, heteroaryl, aryl (C 1 -C 6 -alkyl) - or heteroaryl A (C 1 -C 6 alkyl) group; or R 9 and R 10 together with the nitrogen atom to which they are attached form a heterocyclic ring of 4-8 atoms, optionally containing another nitrogen or oxygen atom, wherein any aryl, heteroaryl, cycloalkyl, aryl-fused to cycloalkyl, heterocycloalkyl , and an aryl-fused to heterocycloalkyl group may be substituted by one or more substituent groups selected from acyl, alkoxy, alkoxycarbonyl, alkylamino, alkylsulfinyl, alkylsulfonyl, alkylthio, -NH2, aminoacyl, aminoalkyl, alkylaminoalkyl, arylalkyl, dialkylaminoalkyl, arylalkylaminoalkyl, arylalkyl halo, haloalkoxy, haloalkyl, alkyl, -OH, - CHO, -COOH, -NO2, aryl (optionally substituted by alkoxy, haloalkoxy, halogen, alkyl or haloalkyl), heteroaryl (optionally substituted by alkoxy, haloalkoxy, halogen, alkyl or hatoalkyl), heterocycloalkyl, aminoacyl, aminosulfonyl, acylamino, sulfonylamino, heteroarylalkyl, cyclic amine, aryloxy, heteroaryloxy, arylalkyloxy and heteroarylalkyloxy; or a pharmaceutically acceptable salt, solvate and or N-oxide of it. The application contains another 39 dependent claims. |
| priorityDate | 2005-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 57.