| abstract |
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: R 1 is selected from R 3 is selected from the group consisting of hydrogen, -CF 3, -NH 2, -OH, alkyl optionally substituted with 1, 2 or 3 R 5, alkoxy, dialkylaminoalkyl , cycloalkyl optionally substituted with arylalkoxy, aryl optionally substituted by 1, 2 or 3 groups selected from halogen, alkyl, alkoxy, dialkylaminoalkoxy and heterocycloalkyl optionally substituted by alkyl or aryl, alkenyl, alkynyl, heterocycloalkyl optionally substituted by group of the following: alkyl, -C (O) O-alkyl and arylalkyl, arylalkyl optionally substituted by alkylheterocycloalkyl at any ring position of the aryl group, and heteroaryl; each R4, R7, R8, R9 and R11 are independently selected from hydrogen, -OR16. -SR16, -N (H) R16, hydroxy, alkenyl, alkynyl, hydroxyalkyl, halogen, hydroxyalkyl, dihydroxyalkyl, -OC (O) -NH2, amino (imino) alkyl, -C (O) -NH2, -N (H ) C (O) alkyl, alkylaminoalkyl, alkylaminoalkylamino, aminoalkylamino, arylalkyl ino, heterocycloalkyl, dialkylaminoalkyl, alkyl optionally substituted by 1-8 halogens, dialkylamino, -N (H) alkylheterocycloalkyl, alkylsulfonylheterocycloalkylamino, cycloalkylalkylamino, cycloalkoxy, -NH2, -O-alkyl-dialkylalkylalkylalkylalkylalkyl, optionally substituted with 1, 2 or 3 groups selected from alkyl, alkoxy and halogen; R 5 is selected from the group consisting of halogen, cycloalkyl, cycloalkylalkylamino, heteroaryl optionally substituted with 1, 2 or 3 groups selected from halogen, alkyl and alkoxy, alkylthio, heterocycloalkyl optionally substituted by 1, 2 or 3 groups selected from alkyl, halogen, phenyl and oxo, aryl optionally substituted by 1, 2 or 3 groups selected from halogen, alkyl, alkoxy, dialkylaminoalkoxy, and heterocycloalkyl optionally substituted with alkyl, alkoxy, dialkylamino, -OH, -C (O) -NH2, -C (O) -O-CH3, -C (O) -N (H) (C1-C3) alkyl, heteroarylamino optionally substituted halogen, and -OCF3; each R6 and R1 O are selected from hydrogen, alkyl optionally substituted with 1-8 halogens. alkylthio, alkenyl. alkynyl, hydroxyalkynyl, halogen, hydroxyalkyl, dihydroxyalkyl. amino (imino) alkyl, -C (O) -NH2, -N (H) C (O) alkyl, alkylaminoalkyl, alkylaminoalkylamino, aminoalkylamino, arylalkylamino, heterocycloalkyl, dialkylaminoalkyl, alkylamino optionally substituted with 1-8 halogens, dialkylamino, alkyloxyamino, alkyloxyamino -N (H) alkylheterocycloalkyl, cycloalkylalkylamino, alkylsulfonylheterocycloalkylamino, cycloalkylalkylamino, cycloalkylamino optionally substituted by a group selected from the following: -OH, alkyl, -CF3 and heterocycloalkyl, -N (H) cycloalkyl, -N (H) cycloalkyl, -N (H) cycloalkyl, -N (H) cycloalkyl NH2, -N (H) -heteroaryl, -N (H) -aryl optionally substituted by 1, 2 or 3 groups selected from alkoxy, heterocycloalkylalkoxy and dialkylaminoalkoxy, alkylsulfonylalkylamino and -N (H) heterocycloalkyl; R16 is selected from the group consisting of Vodona |