| abstract |
A compound of formula I: m is 0 or 1; Z is CN, OR2a, CO2R2a or CON (R2a) 2; R 1b represents: H, C 1-4 alkyl or OH; R1c represents H or C1-4alkyl; Ar1 represents phenyl or pyridyl, both of which carry 0-3 substituents independently selected from: halogen, CN, NO2, CF3, OH, OCF3, C1-4alkoxy or C1-4alkyl, optionally bearing a substituent selected from: hiogen, CN, NO2, CF3, OH and C1-4alkoxy; Ar2 represents phenyl which is substituted at the 2- and 5- positions by halogen; R2a represents: H, C1-6alkyl, C3-6cycloalkyl , C3-6cycloalkylC1-6alkyl, C2-6alkenyl, each optionally bearing a substituent selected from: halogen, CN, NO2, CF3, OR2b, CO2R2b, N (R2b) 2, CON (R2b), Ar and COAr; or R2a represents Ar; or two R2a groups, together with the nitrogen atom to which they are attached, may form an N-heterocyclyl group bearing 0-4 substituents independently selected from: = O, = S, halogen, C1-4alkyl, CN, NO2 , CF3, OH, C1-4alkoxy, C1-4alkoxycarbonyl, CO2H, amino, C1-4alkylamino, di (C1-4alkyl) amino, carbamoyl, Ar and COAr; R2b represents: H, C1-6alkyl, C3-6cycloalkyl, C3- 6cycloalkylC1-6alkyl, C2-6alkenyl, each optionally bearing a substituent selected from: halogen, CN, NO2; CF3, OH, C1-4alkoxy, C1-4alkoxycarbonyl, CO2H, amino, C1-4alkylamino, di (C1-4alkyl) amino, carbamoyl, Ar and COAr; or R2b represents Ar; or two R2b groups, together with the nitrogen atom to which they are attached together, may form an N-heterocyclyl group bearing 0-4 substituents independently selected from: = O, = S, halogen, C1-4alkyl, CN, NO2 , CF3, OH, C1-4alkoxy, C1-4alkoxycarbonyl, CO2H, amino, C1-4alkylamino, di (C1-4alkyl) amino, carbamoyl, Ar and COAr; Ar represents phenyl or heteroaryl bearing 0-3 substituents selected from : halogens, C1-4alkyl, CN, NO2, CF3, OH, C1-4alkoxy, C1-4alkoxycarbonyl, amino, C1-4alkylamino, di (C1-4alkyl) amino, carbamoyl, C1-4alkylcarbamoyl and di (C1-4alkyl) carbamoyl ; or a pharmaceutically acceptable salt thereof. The application contains 12 more claims. |