http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RS-51212-B

Outgoing Links

Predicate Object
assignee http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6572ff5df928fd17340eb2a8cb6d8502
classificationCPCAdditional http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-10
classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/F16B37-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-37
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02
filingDate 2005-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c02db35430c2be4e50eee8f97bc66a7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97a5db8db86245f34b617992b480e751
publicationDate 2010-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RS-51212-B
titleOfInvention NEW PROCESS OF SYNTHESIS (7-METHOXY-1-naphthyl) ACETONITRIL AND APPLICATION IN AGOMELATIN SYNTHESIS
abstract Process for the industrial synthesis of a compound of formula (I) characterized in that 7-methoxy-1-tetralone of formula (IV) is reacted with cyanoacetic acid of formula (V): under conditions of elimination of the water formed, in the presence of a catalytic amount of a compound of formula (VI) : wherein R and R ', the same or different, each represent a linear or branched (C3-C10) alkyl group, an unsubstituted or substituted aryl group, or an unsubstituted or substituted linear or branched (C1-C6) arylalkyl group, in order to after filtration and washing with basic solution, 7 (methoxy-3,4-dihydro-1-naphthalenyl) acetonitrile of formula (VII) is obtained: the compound of formula (VII) is reacted with a hydrogenation catalyst in the presence of an allyl derivative to, after filtration and evaporation of the solvent gave the compound of formula (I), the compound of formula (I) is isolated after recrystallization in the form of a solid, with the understanding that: - aryl means a phenyl, naphthyl or biphenyl group, - the term "substituted" refers to the formulas "aryl" and "arylalkyl" meaning that the aromatic moiety of these groups may be substituted by 1 to 3 of the same or different groups selected from linear or branched (C1-C6) alkyl, hydroxy and linear or branched (C1-C6) alkoxy, -under "allyl derivative" means a complete molecule containing 3 to 10 carbon atoms and may have another 1 to 5 oxygen atoms and, containing at least one motif-CH2-CH = CH2. The application contains 10 more claims.
priorityDate 2004-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

Incoming Links

Predicate Subject
isDiscussedBy http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID458397310
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID456171974
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID458394811
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID9740
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID81276
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419480088
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID458393352
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID457623688
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID82148
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID415772458
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419559502
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID962
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID6342
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419568237
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419512635

Total number of triples: 34.