| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_30ed587317ad9a18467c0752dea305e6 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-4825
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-473
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5057
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0053
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-4858 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-473
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-48 |
| filingDate |
2007-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6fe1bceff4aee5c1c4ed9217ece4f635
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb66c86939ca2759d9bc3475d12b008b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21e1d1c833cf1eecd9555dda680401bd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a6f141df43ec2ca48236ad8ad0f973a |
| publicationDate |
2010-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
RS-50842-B |
| titleOfInvention |
SOFT CAPULOS CONTAINING PALONOSETRONUM HYDROGEN HYDROGEN WITH IMPROVED STABILITY AND bioavailability |
| abstract |
The soft gelatin capsule for oral administration contains: a) a soft gelatinous outer shell having an oxygen permeability of less than about 1.0 x 10 "3 mlcm / (cm2-24hr.atm); and b) a lipophilic liquid inner filling composition containing: i) more from about 50% by weight of one or more lipophilic components, ii) from about 1 to 20% by weight of water-miscible or homogenized said one or more lipophilic components, iii) from about 0.05 to about 2.0 mg of palonosetron as palonosetron hydrochloride dissolved or dispersed iiv) surfactants, wherein said capsule shows pharmacokinetics when ingested orally in the solid state which are bioequivalent to a formulation having more than 95% absolute bioavailability, where bioequivalence is determined by a 90% confidence interval for AUC which is between 80% and 125%. The application contains another 26 patent claims. |
| priorityDate |
2006-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |