http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RS-50820-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_afc5d8c9ee6673323cee3e2d19bc5146 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04 |
| filingDate | 2000-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ef15f7216469d3c70f6aed3743f1978 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d92522c12d306c81ad7378bda023db83 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a9c1d99e730f5640a112257b7ec8f6d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0989aa19622f6a8ad76b64517a85185f |
| publicationDate | 2010-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RS-50820-B |
| titleOfInvention | TRICYCLIC BENZODIAZEPINS AS AN ANTAGONISTS OF VASOPRESIN RECEPTORS |
| abstract | Compound of Formula (I) or (II): wherein I am an integer from 0 to 1, provided that if m is 0 or 1, then the "HET" in the compound of formula (II) is a stable five- or six-membered monocyclic aromatic ring system. composed of carbon atoms and one heteroatom, wherein the heteroatom is selected from N, O or S, and may be in any position of the ring in which the resulting ring system is stable; A is selected from -C (O) -, SO2 and CH2, Y is selected from CH2 or CH as part of an olefin; X is selected from CH2, CH as part of an olefin, NR3, S and O; provided that if Y is CH as part of an olefin, then X is CH as part of an olefin; Z is selected from N and CH; R1 is selected from hydrogen, alkyl, alkoxy, halogen, aminoalkyl and nitro; R2 is selected from the group consisting of NR4COAr, NR4CO-heteroaryl, NR4Ar, CH = CH-Ar, CF = CH-Ar, CH = CF-Ar, CCI = CH-Ar, CH = CCI-Ar, CH = CH-heteroaryl , CF = CH-heteroaryl, CH = CF-heteroaryl, -CCI = CH-heteroaryl, CH = CCI-heteroaryl, OCH2-Ar, OCH2-heteroaryl, SCH2-Ar and NR4CH2Ar; R3 is selected from the group consisting of hydrogen, acyl , alkyl, alkoxycarbonyl, alkylsulfonyl and arylsulfonyl; R4 is selected from the group consisting of hydrogen and C1-C4alkyl; R5 is selected from hydrogen, C1-C4alkyl, C1-C4alkoxy, chlorine, fluorine, hydroxy, dialkylamino (where alkyl groups at amino can Ar is selected from naphthyl, wherein naphthyl is optionally substituted with one to three substituents independently selected from C 1 -C 8 alkyl, C 1 -C 8 alkoxy, fluorinated C 1 -C 8 alkyl, fluorinated C 1 -C 8 alkoxy. halogen, cyano, hydroxy, amino, nitro, C1-C4alkylamino or C1-C4 dialkylamino (where the alkyl groups may be the same or different); or phenyl, wherein the phenyl is optionally substituted with one to three substituents independently selected from C1-C8 alkyl, C1-C8alkoxy, fluorinated C1-C8alkyl, fluorinated C1-C8alkoxy, C1-C8alkyl (where optionally alkyl or aryl moieties are independently substituted, and the alkyl moiety may be substituted by at least one fluorine and / or the aryl moiety may be independently substituted by one to two substituents selected from halogen, C1-C4alkyl, C1-C6alkylthio or hydroxy), C1-C8alkoxy, (where the C1-C10 alkoxy or aryl moieties are independently substituted, and the alkoxy moiety may be substituted by at least one fluorine and / or the aryl moiety may be independently substituted by one to two substituents selected from halogen, C1-C4alkyl, C1-C8alkylthio or hydroxyl). halogen, cyano, hydroxy, amino, nitro, C1-C8alkylamino, C1-C4 dialkylamino (where alkyl groups on amino may be the same or different), C1-C8alkylsulfonyl, C1-C8alkylthio, C1-C8alkylsulfinyl, heteroaryl, other phenyl (where is the second phenyl optionally substituted with one to two substituents independently selected from C1-C4alkyl, C1-C4alkoxy, fluorinated C1-C4alkyl, f |
| priorityDate | 1999-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.