| abstract |
Pentafluorosulfanyl-benzoylguanidines of the formula I or II, characterized in that: R 1 is hydrogen, alkyl having 1, 2, 3 or 4 carbon atoms, alkoxy having 1, 2, 3 or 4 carbon atoms, F, Cl, Br, J, CN, NR10R11, -Op- (CH2) n- (CF2) O-CF3 or - (SOm) q- (CH2) r- (CF2) s-CF3; R10 and R11 are independently one of the preferred hydrogen, alkyl with 1 , 2, 3 or 4 carbon atoms, or -CH2-CF3; M is zero, 1 or 2n, o, p, q, ris are, independently of one of the preferred, zero or 1; R2 is hydrogen, F, Cl, Br, J, -CN, -SO2CH3, - (SOh) z- (CH2) k- (CF2) 1-CF3, alkyl having 1, 2, 3, 4, 5 or 6 C -atoms, cycloalkyl having 3, 4, 5, 6, 7 or 8 carbon atoms, in which 1, 2, 3 or 4 hydrogen atoms can be replaced by fluorine atoms, h is zero, 1 or 2, z is zero or 1; k is zero, 1, 2, 3 or 4; 1 is zero or 1; or R 2 is - (CH 2) t -phenyl or -O-phenyl, which is unsubstituted or substituted by 1, 2 or 3 residues which are selected from the group consisting of F, Cl, Br, J, -Ou- (CH2) v-CF3, alkoxy having 1, 2, 3 or 4 carbon atoms, alkyl having 1,2, 3 or 4 carbon atoms and -SO2CH3, t is zero, 1, 2, 3 or 4, u is zero or 1, v is zero, 1, 2 or 3, or R2 is - (CH2) w-heteroaryl, which is unsubstituted or substituted by 1, 2 or 3 residues selected from the group consisting of F, Cl, Br, J, -Ox- (CH2) y-CF3, alkoxy having 1, 2, 3 or 4 carbon atoms, alkyl having 1, 2, 3 or 4 C-atoms and -SO2CH3; w is zero, 1, 2, 3 or 4; x is zero or 1; y is zero, 1, 2 or 3; R3 and R4 are independently og, hydrogen or F, as well as their pharmaceutically acceptable salts.The application contains 14 more claims. |