| abstract |
A compound of formula I wherein: X is C or N with the proviso that when X is N, R1 does not exist; W is C or N with the proviso that when W is N, R does not exist; V is C; R1 is hydrogen, methoxy or halogen; R3 is methoxy or heteroaryl, each of which may be optionally substituted by one substituent selected from G; wherein heteroaryl is triazolyl, pyrazolyl or oxadiazolyl; E is hydrogen or a pharmaceutically acceptable mono or bis salt thereof; Y is selected from the group consisting of R10, R11, R12, R13, R14, R15, R16, R17 are each independently H or methyl, provided that not more than R10-R17 are equal to methyl; consisting of C (O) -phenyl, C (O) -pyridinyl, pyridinyl, pyrimidinyl, quinolinyl, isoquinolinyl, quinazolinyl, quinoxalinyl, naphthyridinyl, phthalazinyl, azabenzofuryl and azaindolyl, each of which may be independently substituted with one a member selected from the group consisting of methyl, -amino, -NHMe, -NMe2, methoxy, hydroxymethyl and halogen; D is selected from the group consisting of cyano, S (O) 2R24, halogen, C (O) NR21R22, phenyl and heteroaryl; wherein said phenyl or heteroaryl is independently optionally substituted by one to three same or different halogens or from one to three same or different substituents selected from G; wherein heteroaryl is selected from the group consisting of pyridinyl and oxadiazolyl; A is selected from the group consisting of phenyl, pyridinyl, furyl, thienyl, isoxazolyl and oxazolyl, wherein said phenyl, pyridinyl, furyl, thienyl, isoxazolyl and oxazolyl are independently optionally substituted by one to three same or different halogens or from one to three same or different substituents selected from G; G is selected from the group consisting of (C 1-6) alkyl, (C 1-6) alkenyl, phenyl, hydroxy, methoxy, halogen, - NR23C (O) - (C1-6) alkyl, -NR24 R25, -S (O) 2NR24R25 COOR26 and -CONR24R25; wherein said (C1-6) alkyl is optionally substituted by hydroxy, dimethylamino or one to three of the same or different halogens; R26 is selected from the group consisting of hydrogen and (C1-6) alkyl; R20, R21, R22; R23, R24, R25 are independently selected from the group consisting of hydrogen, (C1-6) alkyl and - (CH2) nNR27R28; n is 0-6; and each R27 and R28 are independently H or methyl. The application contains another 30 dependent claims. |