| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69c91bbf0395db010b4806f50d808c4e |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-63 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 |
| filingDate |
2004-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea6ada2ba4eb9b5f730cafd2af74b488
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eddc4747975e850ccf3db0bc644b1756
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3bd1c3d80302f995897188cff5226d68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f90e2efbc6545363ee5de1cb82085407
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c9578743258909380b7d192f83c1819d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37c77c04d3cedd35a210e90a8d2ed9e5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_11523e8af58a0e7e625fc6daee3e7546 |
| publicationDate |
2008-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
RS-20050980-A |
| titleOfInvention |
PROCEDURE FOR THE PREPARATION OF CHIRAL PURE N- (TRANS-4-ISOPROPYL-CYCLOHEXYLCARBONYL) -D-Phenylalanine and Its Crystalline Modifications |
| abstract |
The invention relates to N- (trans-4-isopropylcyclohexylcarbonyl) -D-phenylalanine (nateglinide) in a novel crystalline form "G" and a process for its preparation. Also provided is a process for preparing a chirally pure nateglinide by treating its lower alkyl ester with a base to obtain an alkaline salt and separating the product from said salt by appropriate acid addition. Another aspect of the invention is a process for preparing nateglinide in crystalline "H" form from other crystalline modifications of nateglinide. |
| priorityDate |
2003-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |