| abstract |
Provided are compounds and pharmaceutically acceptable salts of formula (I) thereof that are useful in the treatment of metabolic disorders associated with insulin resistance, leptin resistance or hyperglycemia. The compounds of the present invention include protein tyrosine phosphatase inhibitors, in particular protein tyrosine phosphatase 1B (PTP-1B), which are useful in the treatment of diabetes and other PTP-mediated diseases, such as cancer, neurodegenerative diseases and the like. Also provided are pharmaceutical compositions comprising the compounds of the present invention and methods of treating the aforementioned conditions using such compounds. |