| abstract |
A process for the preparation of novel N-monosubstituted phenylacetic acid amides of the general formula (I) C6H5CH2CONHCH (R) COOC2H5 (I) in which R represents a phenyl and tolyl group, characterized by the reaction of phenylacetic acid, C6H5CH2COOH, with the corresponding ethyl ester of amine and ethyl ester III) H5C2OOCCH (R) NH3Cl (III) where R represents a phenyl or tolyl group, in a mixture of aqueous and organic solvents, or in a suitable inert organic solvent, in the presence of an acid acceptor, preferably triethylamine, using coupling reagent (dicyclohexylcarbodiimide ii N , N'-diisopropylcarbodiimide) |