| abstract |
The present invention relates to tetrahydroquinoline derivatives having the general formula (I), or to a pharmaceutically acceptable salt thereof wherein: R 1 and R 2 are H or Me; R 3 is H, hydroxy, (1-4C) alkoxy, (di) (1-4C) alkylamino (2-4C) alkoxy or (2-6C) heterocycloalkyl (2-4C) alkoxy; R4 is H, OH (1-4C) alkoxy or R7; R5 is H, OH, (1-4C) alkoxy or R7; provided that if R4 represents H, then R5 is not H, OH or (1-4C) alkoxy, and if R5 represents H, then R4 is not H, OH or (1-4C) alkoxy; R 6 is (2-5C) heteroaryl, (6C) aryl, (3-8C) cycloalkyl, (2-6C) heterocycloalkyl or (1-6C) alkyl; R7 is amino, (di) (1-4C) amino, (6C) anylcarbonylamino, (6C) arylcarbonyloxy or (2-5C) heteroarylcarbonylamino, (2-5C) heteroarylcarbonyloxy, R8- (2-4C) alkylamino, R8- 2-4C) alkoxy, R9-methylamino or R9-methoxy; R 8 is hydroxy, amino, (1-4C) alkoxy, (di) - (1-4C) alkylamino, (2-6C) heterocycloalkyl, (2-6C) heterocycloalkyl carbonylamino, (di) (1-4C) alkylamino -carbonylamino, (1-4C) alkoxycarbonylamino, and R9 is aminocarbonyl, (di) (1-4C) alkylaminocarbonyl, (2-5C) heteroaryl or (6C) aryl. The present invention also relates to pharmaceutical compositions containing said derivatives and to the use of these derivatives in the regulation of fertility. |