http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RO-98843-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_34cd20c171d27cfc98de08d1eb461a3a |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02 |
| filingDate | 1984-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0cb9551fd30c59dbe3bb6e6e727ba9fa |
| publicationDate | 1990-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RO-98843-B1 |
| titleOfInvention | PROCEDURE FOR PREPARING A PEPTIDE |
| abstract | The invention relates to a process for synthesizing a peptide having at least two amino acid residues selected from the group consisting of D or L isomers of amino acid residues, wherein at least one amino acid residue is a stereospecific residue of 1-aminocyclopropane -1-carboxylic acid derivatives, characterized in that a diazocomp of the formula R 1 R 2 CH 2, wherein R 1 and R 2 are in any order a pair of substituents selected from the group consisting of -CH 3 and -CH 3, -CH (CH 3) 2 and -H , -CO 2 H and -H, -CO 2 CO 2 H and -H, -CH 2 -CH 3 and -H, - (CH 2) 3 NH 2 and -H, -CH 2 -CH 2 NHC (NH) NH 2 and -H, - (CH 2) and -C 6 H 5 and -H, -H and -H, 4-hydroxyphenyl and -H, 3,4-dihydroxyphenyl and -H, 3-indolyl and -H, 5-hydroxy-3-indoyl and -H, -OH and -H, -SH and -H, -CH2SH and -H, -CH2OH and -H and 4 (S) -imidazolyl and -H, is reacted with a dehydroalanine derivative having the formula wherein R3 is selected from the group consisting of an alkyl group, an aromatic group, an alkoxy group and a group aryloxy wherein R4 is selected from the group consisting of an alkyl group and an aryl group in an aprotic or protic solvent optionally in the presence of a catalyst or light at temperatures in the range of 0 to 30 degrees C to produce a product initiating the reaction followed by decomposition of the initial reaction product at 0-150 ° C in the presence of an aromatic solvent to produce a 1-aminocyclopropane-1-carboxylic acid derivative having the formula wherein the 1-aminocyclopropane-1-carboxylic acid is a mixture of stereoisomers; after which the mixture of stereoisomers is separated by known physical means or bl groups |
| priorityDate | 1984-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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