http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RO-95505-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69b61dda31f1fd520ae4f9192cfac897 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-08 |
| filingDate | 1986-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_168f1a87ae668604efda31e123044a66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_847870ecae80fba1f4ccc28274177fd8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e5581fb50ed46d457231631d6adcd83 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b2355b58cefd87e207441e6b69acb0b7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e5987ed505149f4804169d79f284d3e |
| publicationDate | 1988-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RO-95505-B1 |
| titleOfInvention | PROCEDURE FOR OBTAINING A PRAZOLIDINE DERIVATIVE |
| abstract | The invention relates to a process for the preparation of a pyrazolidine derivative used as a medicine consisting of the molecular combination of clofexamide with phenylbutazone by the initial amidation reaction between 4-chlorophenoxyacetic acid and N, N-diethylaminoethylamine followed by reaction between the resulting acetamide derivative and phenylbutazone , according to the main invention with specification n ° 91023. The process consists in contacting phenylbutazone in the presence of polar solvents selected from acetone, isopropyl alcohol, ethyl alcohol in a ratio of 1: 1 in order to increase the whiteness of the finished product, in the toluene (or xylene) solution of clofenoxide 1: 5 and 1: 6 (by volume) to toluene (or xylene) at 10 ... 25 ° C, the product isolated by filtration at 0-10 ° C is recrystallized from lower alcohols such as, for example, ethyl alcohol. |
| priorityDate | 1986-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.