http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RO-85987-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_76195fd1cd08192222699d8e7a88c231 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D205-08 |
| filingDate | 1981-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74974016bdd4a69c46a6c609539f1462 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe632cda1f8a125553fb6a9504b37e34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4bdba90155bdf2a283016156e06475f6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78a706376bf8892ae4b4e909647bba89 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8a15dcd4d19316bd8eabd81ced78a12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd7e93679977512c5ffc378581ab6ab0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_399542e823f84d2c5adf2b4ff08f02bd |
| publicationDate | 1985-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RO-85987-B1 |
| titleOfInvention | PROCESS FOR THE PREPARATION OF LACTAMES |
| abstract | The invention relates to a process for the preparation of lactams of general formula I wherein R1 represents a phenylacetyl group or a protecting group selected from benzyloxycarbonyl or t-butoxycarbonyl, one of R2 and R3 represents hydrogen and the other hydrogen or lower alkyl and M @ + represents a tetraalkylammonium cation, characterized in that a compound of the general formula (II): wherein R1, R2 and R3 are as defined above and M5 is a leaving group of mesylate, is sulfonated by treatment with chlorosulfonic acid in the presence of 2-methylpyridine at reflux temperature in a halogenated aliphatic hydrocarbon solvent, followed by the addition of tetra-n-butylammonium acid sulphate with the intermediate compound of formula III: (see formula) wherein R 1, R 2, R 3, Ms and M 1a + have the above-mentioned meaning, which is cyclized by treatment with a base selected from an alkali metal carbonate or bicarbonate in an amest e. g. water and a halogenated aliphatic hydrocarbon as the solvent at reflux temperature, then from the compounds of general formula I obtained, the protecting group is removed to obtain a compound wherein R1 is hydrogen and optionally converts the salts of formula I into free acids by methods known per se. |
| priorityDate | 1981-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.