| abstract |
The invention relates to a process for the preparation of phenethanolamine derivatives of general formula I: (wherein R 1 represents a hydrogen or fluorine atom, R 2 represents a hydroxy, aminocarbonyl, methylaminocarbonyl, dimethylaminocarbonyl, acetylamino or methanesulfonylamino, i.e. a styrene oxide derivative of the general formula II: wherein R1 has the above meaning, is reacted with an amine of general formula III: (see form as shown) in which R2 has the abovementioned meanings at the reflux temperature in lower alkanol medium, after which the racemate is cleaved in optically active isomers by known methods. |